Enzyme

Download
EC Tree
     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.1 Phosphotransferases with an alcohol group as acceptor
ID:2.7.1.11
Description:6-phosphofructokinase.
Alternative Name: Phosphohexokinase.
Phosphofructokinase I.
Prosite: PDOC00504; PDOC00336;
PDB:
PDBScop
5C3Y 8029019; 8041398; 8029019; 8041398; 8029019; 8041398; 8029019; 8041398; 8029019; 8041398; 8029019; 8041398; 8029019; 8041398; 8029019; 8041398; 8029019; 8041398; 8029019; 8041398; 8029019; 8041398; 8029019; 8041398;
5C41 8029019; 8041398; 8029019; 8041398; 8029019; 8041398; 8029019; 8041398;
5C40 8029019; 8041398; 8029019; 8041398;
5C3Z 8029019; 8041398; 8029019; 8041398;
5BYF 8029019; 8041398; 8029019; 8041398;
 » show all

Cath: 3.40.1190.20; 3.40.50.450; 3.40.50.460; 3.40.50.1240; 3.40.50.300; 3.10.180.10; 3.10.180.90;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.1.11
BRENDA Enzyme Link: BRENDA 2.7.1.11
KEGG Enzyme Link: KEGG2.7.1.11
BioCyc Enzyme Link: BioCyc 2.7.1.11
ExPASy Enzyme Link: ExPASy2.7.1.11
EC2PDB Enzyme Link: EC2PDB 2.7.1.11
ExplorEnz Enzyme Link: ExplorEnz 2.7.1.11
PRIAM enzyme-specific profiles Link: PRIAM 2.7.1.11
IntEnz Enzyme Link: IntEnz 2.7.1.11
MEDLINE Enzyme Link: MEDLINE 2.7.1.11
MSA:

2.7.1.11;

Phylogenetic Tree:

2.7.1.11;

Uniprot:
M-CSA:
RHEA:16109 ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Crystal structure of human platelet phosphofructokinase-1 locked in an activated conformation.Kloos M, Brüser A, Kirchberger J, Schöneberg T, Sträter N2015 Aug 126205495
Structure and allosteric regulation of eukaryotic 6-phosphofructokinases.Schöneberg T, Kloos M, Brüser A, Kirchberger J, Sträter N2013 Aug23729568
Crystallization and properties of phosphofructokinase from Clostridium pasteurianum.Uyeda K, Kurooka S1970 Jul 104248230
[Study of an enzyme allosteric to 2 substrates: phosphofructokinase of rat muscle. I. Preparation and crystallization of the enzyme].Odeide R, Guilloton M, Dupuis B, Ravon D, Rosenberg AJ19684237772
Crystallization and properties of rabbit skeletal muscle phosphofructokinase.Parmeggiani A, Luft JH, Love DS, Krebs EG1966 Oct 254224472
Phosphonexokinase in higher plants.AXELROD B, SALTMAN P, BANDURSKI RS, BAKER RS1952 May12981037