EC number:2.7.1.127

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.1 Phosphotransferases with an alcohol group as acceptor
ID:2.7.1.127
Description:Inositol-trisphosphate 3-kinase.
Alternative Name: IP3K.
IP3 3-kinase.
Ins(1,4,5)P(3) 3-kinase.
Inositol 1,4,5-trisphosphate 3-kinase.
1D-myo-inositol-trisphosphate 3-kinase.
Cath: 1.10.510.50; 3.30.1490.220; 3.30.470.10; 3.30.470.100; 3.30.470.20; 3.40.50.10820; 3.40.50.11370;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.1.127
BRENDA Enzyme Link: BRENDA 2.7.1.127
KEGG Enzyme Link: KEGG2.7.1.127
BioCyc Enzyme Link: BioCyc 2.7.1.127
ExPASy Enzyme Link: ExPASy2.7.1.127
EC2PDB Enzyme Link: EC2PDB 2.7.1.127
ExplorEnz Enzyme Link: ExplorEnz 2.7.1.127
PRIAM enzyme-specific profiles Link: PRIAM 2.7.1.127
IntEnz Enzyme Link: IntEnz 2.7.1.127
MEDLINE Enzyme Link: MEDLINE 2.7.1.127

EC number:2.7.1.127

MSA:

2.7.1.127;
Phylogenetic Tree:

2.7.1.127;
Uniprot:
M-CSA:
RHEA:11020 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Active site labelling of inositol 1,4,5-trisphosphate 3-kinase A by phenylglyoxal.Communi D, Lecocq R, Vanweyenberg V, Erneux C1995 Aug 157646431
Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver.Hansen CA, Mah S, Williamson JR1986 Jun 253487541
The inositol tris/tetrakisphosphate pathway--demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues.Irvine RF, Letcher AJ, Heslop JP, Berridge MJ1986 Apr 17-233010126
Interaction of the catalytic domain of inositol 1,4,5-trisphosphate 3-kinase A with inositol phosphate analogues.Poinas A, Backers K, Riley AM, Mills SJ, Moreau C, Potter BV, Erneux C2005 Aug15997461
Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase.Miller GJ, Hurley JH2004 Sep 1015350215
Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase.González B, Schell MJ, Letcher AJ, Veprintsev DB, Irvine RF, Williams RL2004 Sep 1015350214
Back in the water: the return of the inositol phosphates.Irvine RF, Schell MJ2001 May11331907