EC number:2.7.1.130

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.1 Phosphotransferases with an alcohol group as acceptor
ID:2.7.1.130
Description:Tetraacyldisaccharide 4'-kinase.
Alternative Name: Lipid-A 4'-kinase.
Cath: 1.20.1180.10; 2.160.10.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.1.130
BRENDA Enzyme Link: BRENDA 2.7.1.130
KEGG Enzyme Link: KEGG2.7.1.130
BioCyc Enzyme Link: BioCyc 2.7.1.130
ExPASy Enzyme Link: ExPASy2.7.1.130
EC2PDB Enzyme Link: EC2PDB 2.7.1.130
ExplorEnz Enzyme Link: ExplorEnz 2.7.1.130
PRIAM enzyme-specific profiles Link: PRIAM 2.7.1.130
IntEnz Enzyme Link: IntEnz 2.7.1.130
MEDLINE Enzyme Link: MEDLINE 2.7.1.130

EC number:2.7.1.130

MSA:

2.7.1.130;
Phylogenetic Tree:

2.7.1.130;
Uniprot:
M-CSA:
RHEA:20700 ATP + lipid A disaccharide (E. coli) = ADP + H(+) + lipid IVA (E. coli)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:1]-[O;H0;+0:2]-[P;H0;+0:4](=[*:3])(-[*:5])-[*:6].[*:8]-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Identification of the gene encoding the Escherichia coli lipid A 4'-kinase. Facile phosphorylation of endotoxin analogs with recombinant LpxK.Garrett TA, Kadrmas JL, Raetz CR1997 Aug 299268317
The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4'-phosphate of lipid A.Ray BL, Raetz CR1987 Jan 253027079
Mechanistic characterization of the tetraacyldisaccharide-1-phosphate 4'-kinase LpxK involved in lipid A biosynthesis.Emptage RP, Pemble CW 4th, York JD, Raetz CR, Zhou P2013 Apr 223464738
Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface.Emptage RP, Daughtry KD, Pemble CW 4th, Raetz CR2012 Aug 722826246