EC number:2.7.1.134

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.1 Phosphotransferases with an alcohol group as acceptor
ID:2.7.1.134
Description:Inositol-tetrakisphosphate 1-kinase.
Alternative Name: Inositol-trisphosphate 6-kinase.
Inositol-trisphosphate 5-kinase.
1D-myo-inositol-trisphosphate 6-kinase.
1D-myo-inositol-trisphosphate 5-kinase.
1D-myo-inositol-tetrakisphosphate 1-kinase.
Prosite: PDOC50975;
PDB:
PDBScop
5CAE 8058549; 8058550; 8058551; 8058552; 8057674; 8057675; 8057676; 8057677;
3UFX 8057670; 8057671; 8057672; 8057673; 8057670; 8057671; 8057672; 8057673; 8057670; 8057671; 8057672; 8057673; 8057670; 8057671; 8057672; 8057673;
1KEE 8031531; 8031766; 8043909; 8044144; 8031531; 8031766; 8043909; 8044144; 8024182; 8024184; 8025752; 8031796; 8031852; 8031854; 8036561; 8036563; 8038131; 8044174; 8044230; 8044232; 8024182; 8024184; 8025752; 8031796; 8031852; 8031854; 8036561; 8036563; 8038131; 8044174; 8044230; 8044232; 8031531; 8031766; 8043909; 8044144; 8031531; 8031766; 8043909; 8044144; 8024182; 8024184; 8025752; 8031796; 8031852; 8031854; 8036561; 8036563; 8038131; 8044174; 8044230; 8044232; 8024182; 8024184; 8025752; 8031796; 8031852; 8031854; 8036561; 8036563; 8038131; 8044174; 8044230; 8044232;
1CS0 8031531; 8031766; 8043909; 8044144; 8031531; 8031766; 8043909; 8044144; 8024182; 8024184; 8025752; 8031796; 8031852; 8031854; 8036561; 8036563; 8038131; 8044174; 8044230; 8044232; 8024182; 8024184; 8025752; 8031796; 8031852; 8031854; 8036561; 8036563; 8038131; 8044174; 8044230; 8044232; 8031531; 8031766; 8043909; 8044144; 8031531; 8031766; 8043909; 8044144; 8024182; 8024184; 8025752; 8031796; 8031852; 8031854; 8036561; 8036563; 8038131; 8044174; 8044230; 8044232; 8024182; 8024184; 8025752; 8031796; 8031852; 8031854; 8036561; 8036563; 8038131; 8044174; 8044230; 8044232;
1C3O 8031531; 8031766; 8043909; 8044144; 8031531; 8031766; 8043909; 8044144; 8024182; 8024184; 8025752; 8031796; 8031852; 8031854; 8036561; 8036563; 8038131; 8044174; 8044230; 8044232; 8024182; 8024184; 8025752; 8031796; 8031852; 8031854; 8036561; 8036563; 8038131; 8044174; 8044230; 8044232; 8031531; 8031766; 8043909; 8044144; 8031531; 8031766; 8043909; 8044144; 8024182; 8024184; 8025752; 8031796; 8031852; 8031854; 8036561; 8036563; 8038131; 8044174; 8044230; 8044232; 8024182; 8024184; 8025752; 8031796; 8031852; 8031854; 8036561; 8036563; 8038131; 8044174; 8044230; 8044232;
 » show all
Cath: 3.30.1490.220; 3.30.470.10; 3.30.470.100; 3.30.470.20; 3.40.50.10820; 3.40.50.11370;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.1.134
BRENDA Enzyme Link: BRENDA 2.7.1.134
KEGG Enzyme Link: KEGG2.7.1.134
BioCyc Enzyme Link: BioCyc 2.7.1.134
ExPASy Enzyme Link: ExPASy2.7.1.134
EC2PDB Enzyme Link: EC2PDB 2.7.1.134
ExplorEnz Enzyme Link: ExplorEnz 2.7.1.134
PRIAM enzyme-specific profiles Link: PRIAM 2.7.1.134
IntEnz Enzyme Link: IntEnz 2.7.1.134
MEDLINE Enzyme Link: MEDLINE 2.7.1.134

EC number:2.7.1.134

MSA:

2.7.1.134;
Phylogenetic Tree:

2.7.1.134;
Uniprot:
M-CSA:
RHEA:12452 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.Wilson MP, Majerus PW1996 May 178662638
Metabolism of inositol 1,3,4-trisphosphate to a new tetrakisphosphate isomer in angiotensin-stimulated adrenal glomerulosa cells.Balla T, Guillemette G, Baukal AJ, Catt KJ1987 Jul 253497156
L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase.Stephens LR, Hawkins PT, Morris AJ, Downes PC1988 Jan 12829850
Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate.Shears SB, Parry JB, Tang EK, Irvine RF, Michell RH, Kirk CJ1987 Aug 152823793
The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase.Shears SB1989 Nov 252584198
Arabidopsis thaliana inositol 1,3,4-trisphosphate 5/6-kinase 4 (AtITPK4) is an outlier to a family of ATP-grasp fold proteins from Arabidopsis.Sweetman D, Stavridou I, Johnson S, Green P, Caddick SE, Brearley CA2007 Sep 417698066
Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase.Ho MW, Yang X, Carew MA, Zhang T, Hua L, Kwon YU, Chung SK, Adelt S, Vogel G, Riley AM, Potter BV, Shears SB2002 Mar 1911909533
Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase.Yang X, Shears SB2000 Nov 111042108
An Entamoeba histolytica inositol 1,3,4-trisphosphate 5/6-kinase has a novel 3-kinase activity.Field J, Wilson MP, Mai Z, Majerus PW, Samuelson J2000 Apr 3010802324