EC number:2.7.1.137
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.1 Phosphotransferases with an alcohol group as acceptor |
| ID: | 2.7.1.137 | ||
|---|---|---|---|
| Description: | Phosphatidylinositol 3-kinase. | ||
| Alternative Name: |
Type III phosphoinositide 3-kinase. Type I phosphatidylinositol kinase. PtdIns-3-kinase. PI3-kinase. 1-phosphatidylinositol 3-kinase. | ||
| Prosite: | PDOC00710; | ||
| PDB: |
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| Cath: | 1.10.1070.11; 3.30.1010.10; 1.25.40.70; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.1.137 |
| BRENDA Enzyme Link: | BRENDA 2.7.1.137 |
| KEGG Enzyme Link: | KEGG2.7.1.137 |
| BioCyc Enzyme Link: | BioCyc 2.7.1.137 |
| ExPASy Enzyme Link: | ExPASy2.7.1.137 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.1.137 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.1.137 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.1.137 |
| IntEnz Enzyme Link: | IntEnz 2.7.1.137 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.1.137 |
EC number:2.7.1.137
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:12709 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 3-phosphate) + ADP + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites. | Suer S, Sickmann A, Meyer HE, Herberg FW, Heilmeyer LM Jr | 2001 Apr | 11277933 |
| p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. | Chantry D, Vojtek A, Kashishian A, Holtzman DA, Wood C, Gray PW, Cooper JA, Hoekstra MF | 1997 Aug 1 | 9235916 |
| A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. | Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD | 1995 Jul 17 | 7628435 |
| Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity. | Resnick AC, Snowman AM, Kang BN, Hurt KJ, Snyder SH, Saiardi A | 2005 Sep 6 | 16123124 |
| Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. | Arcaro A, Zvelebil MJ, Wallasch C, Ullrich A, Waterfield MD, Domin J | 2000 Jun | 10805725 |