EC number:2.7.1.138
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.1 Phosphotransferases with an alcohol group as acceptor |
| ID: | 2.7.1.138 | ||
|---|---|---|---|
| Description: | Ceramide kinase. | ||
| Alternative Name: |
Acylsphingosine kinase. | ||
| Prosite: | PDOC50146; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.1.138 |
| BRENDA Enzyme Link: | BRENDA 2.7.1.138 |
| KEGG Enzyme Link: | KEGG2.7.1.138 |
| BioCyc Enzyme Link: | BioCyc 2.7.1.138 |
| ExPASy Enzyme Link: | ExPASy2.7.1.138 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.1.138 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.1.138 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.1.138 |
| IntEnz Enzyme Link: | IntEnz 2.7.1.138 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.1.138 |
EC number:2.7.1.138
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:17929 | an N-acylsphing-4-enine + ATP = ADP + H(+) + N-acylsphing-4-enine 1-phosphate |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles. | Bajjalieh SM, Martin TF, Floor E | 1989 Aug 25 | 2547795 |
| A conserved cysteine motif is critical for rice ceramide kinase activity and function. | Bi FC, Zhang QF, Liu Z, Fang C, Li J, Su JB, Greenberg JT, Wang HB, Yao N | 2011 Mar 31 | 21483860 |
| A lipid binding domain in sphingosine kinase 2. | Don AS, Rosen H | 2009 Feb 27 | 19168031 |
| Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies. | Van Overloop H, Gijsbers S, Van Veldhoven PP | 2006 Feb | 16269826 |
| MuLK, a eukaryotic multi-substrate lipid kinase. | Waggoner DW, Johnson LB, Mann PC, Morris V, Guastella J, Bajjalieh SM | 2004 Sep 10 | 15252046 |
| Ceramides modulate programmed cell death in plants. | Liang H, Yao N, Song JT, Luo S, Lu H, Greenberg JT | 2003 Nov 1 | 14563678 |