EC number:2.7.1.149

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.1 Phosphotransferases with an alcohol group as acceptor
ID:2.7.1.149
Description:1-phosphatidylinositol-5-phosphate 4-kinase.
Alternative Name: Type II PIP kinase.
Cath: 3.30.800.10; 3.30.810.10; 1.20.58.1870;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.1.149
BRENDA Enzyme Link: BRENDA 2.7.1.149
KEGG Enzyme Link: KEGG2.7.1.149
BioCyc Enzyme Link: BioCyc 2.7.1.149
ExPASy Enzyme Link: ExPASy2.7.1.149
EC2PDB Enzyme Link: EC2PDB 2.7.1.149
ExplorEnz Enzyme Link: ExplorEnz 2.7.1.149
PRIAM enzyme-specific profiles Link: PRIAM 2.7.1.149
IntEnz Enzyme Link: IntEnz 2.7.1.149
MEDLINE Enzyme Link: MEDLINE 2.7.1.149

EC number:2.7.1.149

MSA:

2.7.1.149;
Phylogenetic Tree:

2.7.1.149;
Uniprot:
M-CSA:
RHEA:12280 a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:1]-[O;H0;+0:2]-[P;H0;+0:4](=[*:3])(-[*:5])-[*:6].[*:8]-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.Rameh LE, Tolias KF, Duckworth BC, Cantley LC1997 Nov 139367159