EC number:2.7.1.151

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.1 Phosphotransferases with an alcohol group as acceptor
ID:2.7.1.151
Description:Inositol-polyphosphate multikinase.
Alternative Name: IpK2.
IP3/IP4 dual-specificity 6-/3-kinase.
IP3/IP4 6-/3-kinase.
Inositol polyphosphate 6-/3-/5-kinase.
Cath: 1.10.510.50; 3.30.1490.220; 3.30.470.10; 3.30.470.100; 3.30.470.20; 3.40.50.10820; 3.40.50.11370;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.1.151
BRENDA Enzyme Link: BRENDA 2.7.1.151
KEGG Enzyme Link: KEGG2.7.1.151
BioCyc Enzyme Link: BioCyc 2.7.1.151
ExPASy Enzyme Link: ExPASy2.7.1.151
EC2PDB Enzyme Link: EC2PDB 2.7.1.151
ExplorEnz Enzyme Link: ExplorEnz 2.7.1.151
PRIAM enzyme-specific profiles Link: PRIAM 2.7.1.151
IntEnz Enzyme Link: IntEnz 2.7.1.151
MEDLINE Enzyme Link: MEDLINE 2.7.1.151

EC number:2.7.1.151

MSA:

2.7.1.151;
Phylogenetic Tree:

2.7.1.151;
Uniprot:
M-CSA:
RHEA:32359 1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)
RULE(radius=1) ([*:1]-[OH;+0:2].[*:3]-[OH;+0:4]).[*:5]=[P;H0;+0:6](-[*:7])(-[*:8])-[O;H0;+0:9]-[*:10].[*:11]=[P;H0;+0:12](-[*:13])(-[*:14])-[O;H0;+0:15]-[*:16]>>[*:16]-[OH;+0:15].[*:10]-[OH;+0:9].([*:5]=[P;H0;+0:6](-[*:7])(-[*:8])-[O;H0;+0:2]-[*:1].[*:11]=[P;H0;+0:12](-[*:13])(-[*:14])-[O;H0;+0:4]-[*:3])
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The pathway for the production of inositol hexakisphosphate in human cells.Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW2005 Jan 2115531582
Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.Stevenson-Paulik J, Odom AR, York JD2002 Nov 812226109
The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization.Nalaskowski MM, Deschermeier C, Fanick W, Mayr GW2002 Sep 112027805
A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.Odom AR, Stahlberg A, Wente SR, York JD2000 Mar 1710720331
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH1999 Nov 1810574768