EC number:2.7.1.153

Enzyme

Download
EC Tree
     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.1 Phosphotransferases with an alcohol group as acceptor
ID:2.7.1.153
Description:Phosphatidylinositol-4,5-bisphosphate 3-kinase.
Alternative Name: Type I phosphoinositide 3-kinase.
Cath: 1.10.1070.11; 3.30.1010.10; 1.25.40.70; 2.60.40.150; 3.10.20.760; 3.10.20.770; 3.10.20.90;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.1.153
BRENDA Enzyme Link: BRENDA 2.7.1.153
KEGG Enzyme Link: KEGG2.7.1.153
BioCyc Enzyme Link: BioCyc 2.7.1.153
ExPASy Enzyme Link: ExPASy2.7.1.153
EC2PDB Enzyme Link: EC2PDB 2.7.1.153
ExplorEnz Enzyme Link: ExplorEnz 2.7.1.153
PRIAM enzyme-specific profiles Link: PRIAM 2.7.1.153
IntEnz Enzyme Link: IntEnz 2.7.1.153
MEDLINE Enzyme Link: MEDLINE 2.7.1.153

EC number:2.7.1.153

MSA:

2.7.1.153;
Phylogenetic Tree:

2.7.1.153;
Uniprot:
M-CSA:
RHEA:21292 a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:1]-[O;H0;+0:2]-[P;H0;+0:4](=[*:3])(-[*:5])-[*:6].[*:8]-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity.Resnick AC, Snowman AM, Kang BN, Hurt KJ, Snyder SH, Saiardi A2005 Sep 616123124
Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms.Meier TI, Cook JA, Thomas JE, Radding JA, Horn C, Lingaraj T, Smith MC2004 Jun15135396