EC number:2.7.1.154
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.1 Phosphotransferases with an alcohol group as acceptor |
| ID: | 2.7.1.154 | ||
|---|---|---|---|
| Description: | Phosphatidylinositol-4-phosphate 3-kinase. | ||
| Alternative Name: |
Type II phosphoinositide 3-kinase. Phosphoinositide 3-kinase. C2-domain-containing phosphoinositide 3-kinase. | ||
| Prosite: | PDOC00710; | ||
| PDB: |
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| Cath: | 3.30.1520.10; 2.60.40.150; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.1.154 |
| BRENDA Enzyme Link: | BRENDA 2.7.1.154 |
| KEGG Enzyme Link: | KEGG2.7.1.154 |
| BioCyc Enzyme Link: | BioCyc 2.7.1.154 |
| ExPASy Enzyme Link: | ExPASy2.7.1.154 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.1.154 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.1.154 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.1.154 |
| IntEnz Enzyme Link: | IntEnz 2.7.1.154 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.1.154 |
EC number:2.7.1.154
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:18373 | 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:1]-[O;H0;+0:2]-[P;H0;+0:4](=[*:3])(-[*:5])-[*:6].[*:8]-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain. | Virbasius JV, Guilherme A, Czech MP | 1996 Jun 7 | 8663140 |
| Synthesis and function of 3-phosphorylated inositol lipids. | Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD | 2001 | 11395417 |
| Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity. | Resnick AC, Snowman AM, Kang BN, Hurt KJ, Snyder SH, Saiardi A | 2005 Sep 6 | 16123124 |
| Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. | Arcaro A, Zvelebil MJ, Wallasch C, Ullrich A, Waterfield MD, Domin J | 2000 Jun | 10805725 |