EC number:2.7.1.158
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.1 Phosphotransferases with an alcohol group as acceptor |
| ID: | 2.7.1.158 |
|---|---|
| Description: | Inositol-pentakisphosphate 2-kinase. |
| Alternative Name: |
IP5 2-kinase. Ins(1,3,4,5,6)P(5) 2-kinase. Inositol polyphosphate kinase. Inositol 1,3,4,5,6-pentakisphosphate 2-kinase. |
| Cath: | 1.10.510.50; 3.30.1490.220; 3.30.200.110; 3.30.470.10; 3.30.470.100; 3.30.470.20; 3.40.50.10820; 3.40.50.11370; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.1.158 |
| BRENDA Enzyme Link: | BRENDA 2.7.1.158 |
| KEGG Enzyme Link: | KEGG2.7.1.158 |
| BioCyc Enzyme Link: | BioCyc 2.7.1.158 |
| ExPASy Enzyme Link: | ExPASy2.7.1.158 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.1.158 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.1.158 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.1.158 |
| IntEnz Enzyme Link: | IntEnz 2.7.1.158 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.1.158 |
EC number:2.7.1.158
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:20313 | 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation. | Ongusaha PP, Hughes PJ, Davey J, Michell RH | 1998 Nov 1 | 9794810 |
| Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1). | Sweetman D, Johnson S, Caddick SE, Hanke DE, Brearley CA | 2006 Feb 15 | 16223361 |
| Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases. | Stevenson-Paulik J, Bastidas RJ, Chiou ST, Frye RA, York JD | 2005 Aug 30 | 16107538 |
| Inositol polyphosphates regulate zebrafish left-right asymmetry. | Sarmah B, Latimer AJ, Appel B, Wente SR | 2005 Jul | 15992547 |
| A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells. | Fujii M, York JD | 2005 Jan 14 | 15528195 |
| The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase. | Verbsky JW, Wilson MP, Kisseleva MV, Majerus PW, Wente SR | 2002 Aug 30 | 12084730 |
| Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases. | Stevenson-Paulik J, Odom AR, York JD | 2002 Nov 8 | 12226109 |