EC number:2.7.1.159

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.1 Phosphotransferases with an alcohol group as acceptor
ID:2.7.1.159
Description:Inositol-1,3,4-trisphosphate 5/6-kinase.
Alternative Name: IP56K.
Ins(1,3,4)P(3) 5/6-kinase.
Inositol trisphosphate 5/6-kinase.
Prosite: PDOC50975;
PDB:
PDBScop
Cath: 3.30.1490.220; 3.30.470.10; 3.30.470.100; 3.30.470.20; 3.40.50.10820; 3.40.50.11370;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.1.159
BRENDA Enzyme Link: BRENDA 2.7.1.159
KEGG Enzyme Link: KEGG2.7.1.159
BioCyc Enzyme Link: BioCyc 2.7.1.159
ExPASy Enzyme Link: ExPASy2.7.1.159
EC2PDB Enzyme Link: EC2PDB 2.7.1.159
ExplorEnz Enzyme Link: ExplorEnz 2.7.1.159
PRIAM enzyme-specific profiles Link: PRIAM 2.7.1.159
IntEnz Enzyme Link: IntEnz 2.7.1.159
MEDLINE Enzyme Link: MEDLINE 2.7.1.159

EC number:2.7.1.159

MSA:

2.7.1.159;
Phylogenetic Tree:

2.7.1.159;
Uniprot:
M-CSA:
RHEA:20940 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.Wilson MP, Majerus PW1996 May 178662638
Arabidopsis thaliana inositol 1,3,4-trisphosphate 5/6-kinase 4 (AtITPK4) is an outlier to a family of ATP-grasp fold proteins from Arabidopsis.Sweetman D, Stavridou I, Johnson S, Green P, Caddick SE, Brearley CA2007 Sep 417698066
Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.Miller GJ, Wilson MP, Majerus PW, Hurley JH2005 Apr 1515837423
The pathway for the production of inositol hexakisphosphate in human cells.Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW2005 Jan 2115531582
An Entamoeba histolytica inositol 1,3,4-trisphosphate 5/6-kinase has a novel 3-kinase activity.Field J, Wilson MP, Mai Z, Majerus PW, Samuelson J2000 Apr 3010802324
Characterization of a cDNA encoding Arabidopsis thaliana inositol 1,3,4-trisphosphate 5/6-kinase.Wilson MP, Majerus PW1997 Mar 279126335
RHEA:13253 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.Wilson MP, Majerus PW1996 May 178662638
Arabidopsis thaliana inositol 1,3,4-trisphosphate 5/6-kinase 4 (AtITPK4) is an outlier to a family of ATP-grasp fold proteins from Arabidopsis.Sweetman D, Stavridou I, Johnson S, Green P, Caddick SE, Brearley CA2007 Sep 417698066
Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.Miller GJ, Wilson MP, Majerus PW, Hurley JH2005 Apr 1515837423
The pathway for the production of inositol hexakisphosphate in human cells.Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW2005 Jan 2115531582
An Entamoeba histolytica inositol 1,3,4-trisphosphate 5/6-kinase has a novel 3-kinase activity.Field J, Wilson MP, Mai Z, Majerus PW, Samuelson J2000 Apr 3010802324