EC number:2.7.1.178

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.1 Phosphotransferases with an alcohol group as acceptor
ID:2.7.1.178
Description:2-dehydro-3-deoxyglucono/galactono-kinase.
Alternative Name: KDG kinase.
2-keto-3-deoxy-D-gluconate kinase.
Cath: 3.40.1190.20;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.1.178
BRENDA Enzyme Link: BRENDA 2.7.1.178
KEGG Enzyme Link: KEGG2.7.1.178
BioCyc Enzyme Link: BioCyc 2.7.1.178
ExPASy Enzyme Link: ExPASy2.7.1.178
EC2PDB Enzyme Link: EC2PDB 2.7.1.178
ExplorEnz Enzyme Link: ExplorEnz 2.7.1.178
PRIAM enzyme-specific profiles Link: PRIAM 2.7.1.178
IntEnz Enzyme Link: IntEnz 2.7.1.178
MEDLINE Enzyme Link: MEDLINE 2.7.1.178

EC number:2.7.1.178

MSA:

2.7.1.178;
Phylogenetic Tree:

2.7.1.178;
Uniprot:
M-CSA:
RHEA:16525 2-dehydro-3-deoxy-D-galactonate + ATP = 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Characterization of Sulfolobus solfataricus 2-keto-3-deoxy-D-gluconate kinase in the modified Entner-Doudoroff pathway.Kim S, Lee SB2006 Jun16794308
Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus.Lamble HJ, Theodossis A, Milburn CC, Taylor GL, Bull SD, Hough DW, Danson MJ2005 Dec 1916330030
RHEA:14797 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Characterization of Sulfolobus solfataricus 2-keto-3-deoxy-D-gluconate kinase in the modified Entner-Doudoroff pathway.Kim S, Lee SB2006 Jun16794308
Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus.Lamble HJ, Theodossis A, Milburn CC, Taylor GL, Bull SD, Hough DW, Danson MJ2005 Dec 1916330030
Uronic acid metabolism in bacteria. IV. Purification and properties of 2-keto-3-deoxy-D-gluconokinase in Escherichia coli.CYNKIN MA, ASHWELL G1960 Jun13813474
Prediction of enzymatic pathways by integrative pathway mapping.Calhoun S, Korczynska M, Wichelecki DJ, San Francisco B, Zhao S, Rodionov DA, Vetting MW, Al-Obaidi NF, Lin H, O'Meara MJ, Scott DA, Morris JH, Russel D, Almo SC, Osterman AL, Gerlt JA, Jacobson MP, Shoichet BK, Sali A2018 Jan 2929377793