EC number:2.7.1.183

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.1 Phosphotransferases with an alcohol group as acceptor
ID:2.7.1.183
Description:Glycoprotein-mannosyl O(6)-kinase.
Alternative Name: Protein O-mannose kinase.
Cath: 1.10.510.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.1.183
BRENDA Enzyme Link: BRENDA 2.7.1.183
KEGG Enzyme Link: KEGG2.7.1.183
BioCyc Enzyme Link: BioCyc 2.7.1.183
ExPASy Enzyme Link: ExPASy2.7.1.183
EC2PDB Enzyme Link: EC2PDB 2.7.1.183
ExplorEnz Enzyme Link: ExplorEnz 2.7.1.183
PRIAM enzyme-specific profiles Link: PRIAM 2.7.1.183
IntEnz Enzyme Link: IntEnz 2.7.1.183
MEDLINE Enzyme Link: MEDLINE 2.7.1.183

EC number:2.7.1.183

MSA:

2.7.1.183;
Phylogenetic Tree:

2.7.1.183;
Uniprot:
M-CSA:
RHEA:52616 ATP + O(3)-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] = ADP + H(+) + O(3)-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-threonyl-[protein]
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:1]-[O;H0;+0:2]-[P;H0;+0:4](=[*:3])(-[*:5])-[*:6].[*:8]-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP2013 Aug 2323929950
3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy.Nagae M, Mishra SK, Neyazaki M, Oi R, Ikeda A, Matsugaki N, Akashi S, Manya H, Mizuno M, Yagi H, Kato K, Senda T, Endo T, Nogi T, Yamaguchi Y2017 Apr28251761
RHEA:52604 ATP + O(3)-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] = ADP + H(+) + O(3)-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein]
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:1]-[O;H0;+0:2]-[P;H0;+0:4](=[*:3])(-[*:5])-[*:6].[*:8]-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP2013 Aug 2323929950
3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy.Nagae M, Mishra SK, Neyazaki M, Oi R, Ikeda A, Matsugaki N, Akashi S, Manya H, Mizuno M, Yagi H, Kato K, Senda T, Endo T, Nogi T, Yamaguchi Y2017 Apr28251761