EC number:2.7.1.190

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.1 Phosphotransferases with an alcohol group as acceptor
ID:2.7.1.190
Description:Aminoglycoside 2''-phosphotransferase.
Alternative Name: Gentamicin phosphotransferase.
Gentamicin kinase.
APH(2'').
Aminoglycoside (2'') kinase.
Cath: 3.30.200.20; 3.40.630.30; 3.90.1200.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.1.190
BRENDA Enzyme Link: BRENDA 2.7.1.190
KEGG Enzyme Link: KEGG2.7.1.190
BioCyc Enzyme Link: BioCyc 2.7.1.190
ExPASy Enzyme Link: ExPASy2.7.1.190
EC2PDB Enzyme Link: EC2PDB 2.7.1.190
ExplorEnz Enzyme Link: ExplorEnz 2.7.1.190
PRIAM enzyme-specific profiles Link: PRIAM 2.7.1.190
IntEnz Enzyme Link: IntEnz 2.7.1.190
MEDLINE Enzyme Link: MEDLINE 2.7.1.190

EC number:2.7.1.190

MSA:

2.7.1.190;
Phylogenetic Tree:

2.7.1.190;
Uniprot:
M-CSA:
RHEA:48872 a gentamycin + GTP = a gentamycin 2''-phosphate + GDP + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[O;H0;+0:8]-[*:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Nucleotide sequence analysis of the gene specifying the bifunctional 6'-aminoglycoside acetyltransferase 2"-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activities.Ferretti JJ, Gilmore KS, Courvalin P1986 Aug3015884
Revisiting the nucleotide and aminoglycoside substrate specificity of the bifunctional aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia enzyme.Frase H, Toth M, Vakulenko SB2012 Dec 2123115238