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2. Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

ID:

2.7.1.2

Description:

Glucokinase.

Alternative Name:

Glucose kinase.

Prosite:

PDOC00866; PDOC00370;

PDB:

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Cath:

3.30.420.40; 1.25.40.340; 3.40.367.20;

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PDB	Click once to unfold,double click to fold. 3OHR; 3LM9; 1XC3; 2AA4; 2AP1; 4DB3;

UniProtKB Enzyme Link:	UniProtKB 2.7.1.2
BRENDA Enzyme Link:	BRENDA 2.7.1.2
KEGG Enzyme Link:	KEGG2.7.1.2
BioCyc Enzyme Link:	BioCyc 2.7.1.2
ExPASy Enzyme Link:	ExPASy2.7.1.2
EC2PDB Enzyme Link:	EC2PDB 2.7.1.2
ExplorEnz Enzyme Link:	ExplorEnz 2.7.1.2
PRIAM enzyme-specific profiles Link:	PRIAM 2.7.1.2
IntEnz Enzyme Link:	IntEnz 2.7.1.2
MEDLINE Enzyme Link:	MEDLINE 2.7.1.2

RHEA:17825	ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)
RULE(radius=1)	[:1]-[OH;+0:2].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:7]-[:8]>>[:8]-[OH;+0:7].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:2]-[:1]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Mammalian glucokinase and its gene.	Iynedjian PB	1993 Jul 1	8392329
Purification and kinetic characterization of a specific glucokinase from Streptococcus mutans OMZ70 cells.	Porter EV, Chassy BM, Holmlund CE	1982 Dec 20	7150605
Glucokinase of Dictyostelium discoideum.	Baumann P	1969 Dec	4312464
Molecular and cellular regulation of human glucokinase.	Sternisha SM, Miller BG	2019 Mar 15	30641049
Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations.	Heredia VV, Carlson TJ, Garcia E, Sun S	2006 Dec 29	17082186