EC number:2.7.1.32
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.1 Phosphotransferases with an alcohol group as acceptor |
| ID: | 2.7.1.32 |
|---|---|
| Description: | Choline kinase. |
| Cath: | 3.30.200.20; 3.30.200.240; 3.90.1200.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.1.32 |
| BRENDA Enzyme Link: | BRENDA 2.7.1.32 |
| KEGG Enzyme Link: | KEGG2.7.1.32 |
| BioCyc Enzyme Link: | BioCyc 2.7.1.32 |
| ExPASy Enzyme Link: | ExPASy2.7.1.32 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.1.32 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.1.32 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.1.32 |
| IntEnz Enzyme Link: | IntEnz 2.7.1.32 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.1.32 |
| RHEA:12837 | ATP + choline = ADP + H(+) + phosphocholine |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Choline kinase from brewers' yeast. Partial purification, properties, and kinetic mechanism. | Brostrom MA, Browning ET | 1973 Apr 10 | 4572730 |
| Phosphatidylcholine synthesis in castor bean endosperm: characteristics and reversibility of the choline kinase reaction. | Kinney AJ, Moore TS Jr | 1988 Jan | 2829723 |
| Purification and characterization of choline/ethanolamine kinase from rat liver. | Porter TJ, Kent C | 1990 Jan 5 | 2152925 |
| Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. | Gallego-Ortega D, Ramirez de Molina A, Ramos MA, Valdes-Mora F, Barderas MG, Sarmentero-Estrada J, Lacal JC | 2009 Nov 12 | 19915674 |
| Identification of critical residues of choline kinase A2 from Caenorhabditis elegans. | Yuan C, Kent C | 2004 Apr 23 | 14960577 |
| Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization. | Gee P, Kent C | 2003 May 30 | 12758145 |
| Isolation and characterization of the Saccharomyces cerevisiae EKI1 gene encoding ethanolamine kinase. | Kim K, Kim KH, Storey MK, Voelker DR, Carman GM | 1999 May 21 | 10329685 |