EC number:2.7.1.40
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.1 Phosphotransferases with an alcohol group as acceptor |
3D structure
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Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.| PDB |
4IP7;
4IMA;
2VGI;
2VGG;
2VGF;
2VGB;
1PKY;
1E0U;
1E0T;
1A3X;
1A3W;
3HQQ;
3HQP;
1PKL;
3E0V;
3QV7;
3HQO;
3SRK;
3QV8;
3QV6;
3PP7;
3KTX;
3IS4;
3HQN;
3E0W;
1PKM;
3N25;
2G50;
1F3X;
1F3W;
1AQF;
1A5U;
1A49;
1PKN;
6GG6;
6GG5;
6GG4;
6B6U;
5X1W;
5X1V;
5X0I;
5WSC;
5WSB;
5WSA;
5WS9;
5WS8;
5WRP;
4YNG;
4YJ5;
4WJ8;
4RPP;
4QGC;
4QG9;
4QG8;
4QG6;
4KCW;
4KCV;
4KCU;
4KCT;
4JPG;
4HYW;
4HYV;
4G1N;
4FXJ;
4FXF;
4B2D;
3U2Z;
3SRH;
3SRF;
3SRD;
3ME3;
3H6O;
3GR4;
3GQY;
3G2G;
3BJT;
3BJF;
2E28;
1ZJH;
1T5A;
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References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.1.40 |
| BRENDA Enzyme Link: | BRENDA 2.7.1.40 |
| KEGG Enzyme Link: | KEGG2.7.1.40 |
| BioCyc Enzyme Link: | BioCyc 2.7.1.40 |
| ExPASy Enzyme Link: | ExPASy2.7.1.40 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.1.40 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.1.40 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.1.40 |
| IntEnz Enzyme Link: | IntEnz 2.7.1.40 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.1.40 |
| RHEA:56956 | ITP + pyruvate = H(+) + IDP + phosphoenolpyruvate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[CH3;+0:3])=[O;H0;+0:4].[*:5]-[O;H0;+0:6]-[P;H0;+0:7](=[*:8])(-[*:9])-[*:10]>>[*:5]-[OH;+0:6].[*:8]=[P;H0;+0:7](-[*:9])(-[*:10])-[O;H0;+0:4]-[C;H0;+0:2](-[*:1])=[CH2;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of cytosolic pyruvate kinase from banana fruit. | Turner WL, Plaxton WC | 2000 Dec 15 | 11104698 |
| Enzymic synthesis of guanosine and cytidine triphosphates: a note on the nucleotide specificity of the pyruvate phosphokinase reaction. | STROMINGER JL | 1955 Apr | 14389299 |
| Fluorokinase and pyruvic kinase. | TIETZ A, OCHOA S | 1958 Dec | 13618030 |
| Enzymatic phosphorylation of adenosine and 2,6-diaminopurine riboside. | KORNBERG A, PRICER WE Jr | 1951 Dec | 14907737 |
| RHEA:56952 | CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[CH3;+0:3])=[O;H0;+0:4].[*:5]-[O;H0;+0:6]-[P;H0;+0:7](=[*:8])(-[*:9])-[*:10]>>[*:5]-[OH;+0:6].[*:8]=[P;H0;+0:7](-[*:9])(-[*:10])-[O;H0;+0:4]-[C;H0;+0:2](-[*:1])=[CH2;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of cytosolic pyruvate kinase from banana fruit. | Turner WL, Plaxton WC | 2000 Dec 15 | 11104698 |
| Enzymic synthesis of guanosine and cytidine triphosphates: a note on the nucleotide specificity of the pyruvate phosphokinase reaction. | STROMINGER JL | 1955 Apr | 14389299 |
| Fluorokinase and pyruvic kinase. | TIETZ A, OCHOA S | 1958 Dec | 13618030 |
| Pyruvate kinase from Chlamydia trachomatis is activated by fructose-2,6-bisphosphate. | Iliffe-Lee ER, McClarty G | 2002 May | 11994161 |
| Enzymatic phosphorylation of adenosine and 2,6-diaminopurine riboside. | KORNBERG A, PRICER WE Jr | 1951 Dec | 14907737 |
| RHEA:56948 | pyruvate + UTP = H(+) + phosphoenolpyruvate + UDP |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[CH3;+0:3])=[O;H0;+0:4].[*:5]-[O;H0;+0:6]-[P;H0;+0:7](=[*:8])(-[*:9])-[*:10]>>[*:5]-[OH;+0:6].[*:8]=[P;H0;+0:7](-[*:9])(-[*:10])-[O;H0;+0:4]-[C;H0;+0:2](-[*:1])=[CH2;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of cytosolic pyruvate kinase from banana fruit. | Turner WL, Plaxton WC | 2000 Dec 15 | 11104698 |
| Purification and characterization of cytosolic pyruvate kinase from developing seeds of Brassica campestris L. | Singh DK, Malhotra SP, Singh R | 2000 Feb | 10983413 |
| Enzymic synthesis of guanosine and cytidine triphosphates: a note on the nucleotide specificity of the pyruvate phosphokinase reaction. | STROMINGER JL | 1955 Apr | 14389299 |
| Fluorokinase and pyruvic kinase. | TIETZ A, OCHOA S | 1958 Dec | 13618030 |
| Enzymatic phosphorylation of adenosine and 2,6-diaminopurine riboside. | KORNBERG A, PRICER WE Jr | 1951 Dec | 14907737 |
| RHEA:30727 | dATP + pyruvate = dADP + H(+) + phosphoenolpyruvate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[CH3;+0:3])=[O;H0;+0:4].[*:5]=[P;H0;+0:6](-[*:7])(-[*:8])-[O;H0;+0:9]-[*:10]>>[*:10]-[OH;+0:9].[*:5]=[P;H0;+0:6](-[*:7])(-[*:8])-[O;H0;+0:4]-[C;H0;+0:2](-[*:1])=[CH2;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Chemical and enzymatic characterization of recombinant rabbit muscle pyruvate kinase. | Boehme C, Bieber F, Linnemann J, Breitling R, Lorkowski S, Reissmann S | 2013 May | 23324382 |
| Enzymic synthesis of guanosine and cytidine triphosphates: a note on the nucleotide specificity of the pyruvate phosphokinase reaction. | STROMINGER JL | 1955 Apr | 14389299 |
| Fluorokinase and pyruvic kinase. | TIETZ A, OCHOA S | 1958 Dec | 13618030 |
| Enzymatic phosphorylation of adenosine and 2,6-diaminopurine riboside. | KORNBERG A, PRICER WE Jr | 1951 Dec | 14907737 |
| RHEA:30295 | GTP + pyruvate = GDP + H(+) + phosphoenolpyruvate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[CH3;+0:3])=[O;H0;+0:4].[*:5]-[O;H0;+0:6]-[P;H0;+0:7](=[*:8])(-[*:9])-[*:10]>>[*:5]-[OH;+0:6].[*:8]=[P;H0;+0:7](-[*:9])(-[*:10])-[O;H0;+0:4]-[C;H0;+0:2](-[*:1])=[CH2;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of cytosolic pyruvate kinase from banana fruit. | Turner WL, Plaxton WC | 2000 Dec 15 | 11104698 |
| Purification and characterization of cytosolic pyruvate kinase from developing seeds of Brassica campestris L. | Singh DK, Malhotra SP, Singh R | 2000 Feb | 10983413 |
| Enzymic synthesis of guanosine and cytidine triphosphates: a note on the nucleotide specificity of the pyruvate phosphokinase reaction. | STROMINGER JL | 1955 Apr | 14389299 |
| Fluorokinase and pyruvic kinase. | TIETZ A, OCHOA S | 1958 Dec | 13618030 |
| Pyruvate kinase from Chlamydia trachomatis is activated by fructose-2,6-bisphosphate. | Iliffe-Lee ER, McClarty G | 2002 May | 11994161 |
| Enzymatic phosphorylation of adenosine and 2,6-diaminopurine riboside. | KORNBERG A, PRICER WE Jr | 1951 Dec | 14907737 |
| RHEA:18157 | ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[CH3;+0:3])=[O;H0;+0:4].[*:5]=[P;H0;+0:6](-[*:7])(-[*:8])-[O;H0;+0:9]-[*:10]>>[*:10]-[OH;+0:9].[*:5]=[P;H0;+0:6](-[*:7])(-[*:8])-[O;H0;+0:4]-[C;H0;+0:2](-[*:1])=[CH2;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and properties of pyruvate kinase from Bacillus stearothermophilus. | Sakai H, Suzuki K, Imahori K | 1986 Apr | 3711058 |
| Understanding the role of PknJ in Mycobacterium tuberculosis: biochemical characterization and identification of novel substrate pyruvate kinase A. | Arora G, Sajid A, Gupta M, Bhaduri A, Kumar P, Basu-Modak S, Singh Y | 2010 May 24 | 20520732 |
| An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1, 6-bisphosphate. | Ashizawa K, McPhie P, Lin KH, Cheng SY | 1991 Jul 23 | 1854723 |
| Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. | Dombrauckas JD, Santarsiero BD, Mesecar AD | 2005 Jul 12 | 15996096 |
| Mutagenesis of the active site lysine 221 of the pyruvate kinase from Bacillus stearothermophilus. | Sakai H | 2005 Feb | 15749828 |
| Enzymic synthesis of guanosine and cytidine triphosphates: a note on the nucleotide specificity of the pyruvate phosphokinase reaction. | STROMINGER JL | 1955 Apr | 14389299 |
| Fluorokinase and pyruvic kinase. | TIETZ A, OCHOA S | 1958 Dec | 13618030 |
| Pyruvate kinase from Chlamydia trachomatis is activated by fructose-2,6-bisphosphate. | Iliffe-Lee ER, McClarty G | 2002 May | 11994161 |
| Role of lysine 240 in the mechanism of yeast pyruvate kinase catalysis. | Bollenbach TJ, Mesecar AD, Nowak T | 1999 Jul 13 | 10413488 |
| Enzymatic phosphorylation of adenosine and 2,6-diaminopurine riboside. | KORNBERG A, PRICER WE Jr | 1951 Dec | 14907737 |