EC number:2.7.1.48
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.1 Phosphotransferases with an alcohol group as acceptor |
| ID: | 2.7.1.48 |
|---|---|
| Description: | Uridine kinase. |
| Alternative Name: |
Uridine monophosphokinase. |
| Cath: | 3.40.50.300; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.1.48 |
| BRENDA Enzyme Link: | BRENDA 2.7.1.48 |
| KEGG Enzyme Link: | KEGG2.7.1.48 |
| BioCyc Enzyme Link: | BioCyc 2.7.1.48 |
| ExPASy Enzyme Link: | ExPASy2.7.1.48 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.1.48 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.1.48 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.1.48 |
| IntEnz Enzyme Link: | IntEnz 2.7.1.48 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.1.48 |
| RHEA:24674 | ATP + cytidine = ADP + CMP + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase. | Suzuki NN, Koizumi K, Fukushima M, Matsuda A, Inagaki F | 2004 May | 15130468 |
| A pentose bisphosphate pathway for nucleoside degradation in Archaea. | Aono R, Sato T, Imanaka T, Atomi H | 2015 May | 25822915 |
| The phosphofructokinase-B (MJ0406) from Methanocaldococcus jannaschii represents a nucleoside kinase with a broad substrate specificity. | Hansen T, Arnfors L, Ladenstein R, Schönheit P | 2007 Jan | 17021658 |
| RHEA:16825 | ATP + uridine = ADP + H(+) + UMP |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Regulation of enzymic activity by metabolites. I. Uridine-cytidine kinase of Novikoff ascites rat tumor. | Orengo A | 1969 Apr 25 | 5782006 |
| Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase. | Suzuki NN, Koizumi K, Fukushima M, Matsuda A, Inagaki F | 2004 May | 15130468 |
| Reaction of human UMP-CMP kinase with natural and analog substrates. | Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D | 2003 Apr | 12694191 |