EC number:2.7.1.67

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.1 Phosphotransferases with an alcohol group as acceptor
ID:2.7.1.67
Description:1-phosphatidylinositol 4-kinase.
Alternative Name: Type II phosphatidylinositol kinase.
PtdIns-4-kinase.
PI4K-alpha.
PI4-kinase.
PI kinase.
Phosphatidylinositol kinase (phosphorylating).
Phosphatidylinositol kinase.
Phosphatidylinositol 4-kinase.
Prosite: PDOC00710;
PDB:
PDBScop
6EMK 8082137; 8082138; 8082137; 8082138;
4D0L 8057253; 8057254; 8057253; 8057254; 8057253; 8057254;
5FBW 8057253; 8057254;
5FBV 8057253; 8057254;
5FBR 8057253; 8057254;
 » show all
Cath: 1.10.287.2870;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.1.67
BRENDA Enzyme Link: BRENDA 2.7.1.67
KEGG Enzyme Link: KEGG2.7.1.67
BioCyc Enzyme Link: BioCyc 2.7.1.67
ExPASy Enzyme Link: ExPASy2.7.1.67
EC2PDB Enzyme Link: EC2PDB 2.7.1.67
ExplorEnz Enzyme Link: ExplorEnz 2.7.1.67
PRIAM enzyme-specific profiles Link: PRIAM 2.7.1.67
IntEnz Enzyme Link: IntEnz 2.7.1.67
MEDLINE Enzyme Link: MEDLINE 2.7.1.67

EC number:2.7.1.67

MSA:

2.7.1.67;
Phylogenetic Tree:

2.7.1.67;
Uniprot:
M-CSA:
RHEA:19877 a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites.Suer S, Sickmann A, Meyer HE, Herberg FW, Heilmeyer LM Jr2001 Apr11277933
Cloning and characterization of a human phosphatidylinositol 4-kinase.Wong K, Cantley LC1994 Nov 187961848
Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein.Klima M, Tóth DJ, Hexnerova R, Baumlova A, Chalupska D, Tykvart J, Rezabkova L, Sengupta N, Man P, Dubankova A, Humpolickova J, Nencka R, Veverka V, Balla T, Boura E2016 Mar 2427009356
The crystal structure of the phosphatidylinositol 4-kinase IIα.Baumlova A, Chalupska D, Róźycki B, Jovic M, Wisniewski E, Klima M, Dubankova A, Kloer DP, Nencka R, Balla T, Boura E2014 Oct25168678
Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα.Zhou Q, Li J, Yu H, Zhai Y, Gao Z, Liu Y, Pang X, Zhang L, Schulten K, Sun F, Chen C2014 Mar 2824675427
Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network.Minogue S, Chu KM, Westover EJ, Covey DF, Hsuan JJ, Waugh MG2010 Aug20388919
Purification, characterization, and kinetic analysis of a 55-kDa form of phosphatidylinositol 4-kinase from Saccharomyces cerevisiae.Nickels JT Jr, Buxeda RJ, Carman GM1992 Aug 151322897
Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family.Minogue S, Anderson JS, Waugh MG, dos Santos M, Corless S, Cramer R, Hsuan JJ2001 May 1811279162
A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans.Barylko B, Gerber SH, Binns DD, Grichine N, Khvotchev M, Südhof TC, Albanesi JP2001 Mar 1611244087
Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230.Gehrmann T, Gülkan H, Suer S, Herberg FW, Balla A, Vereb G, Mayr GW, Heilmeyer LM Jr1999 Mar 2510101268