EC number:2.7.1.68

Enzyme

Download
EC Tree
     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.1 Phosphotransferases with an alcohol group as acceptor
ID:2.7.1.68
Description:1-phosphatidylinositol-4-phosphate 5-kinase.
Alternative Name: Type I PIP kinase.
PtdIns(4)P-5-kinase.
PIP kinase.
Phosphatidylinositol-4-phosphate 5-kinase.
Phosphatidylinositol 4-phosphate kinase.
Diphosphoinositide kinase.

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.1.68
BRENDA Enzyme Link: BRENDA 2.7.1.68
KEGG Enzyme Link: KEGG2.7.1.68
BioCyc Enzyme Link: BioCyc 2.7.1.68
ExPASy Enzyme Link: ExPASy2.7.1.68
EC2PDB Enzyme Link: EC2PDB 2.7.1.68
ExplorEnz Enzyme Link: ExplorEnz 2.7.1.68
PRIAM enzyme-specific profiles Link: PRIAM 2.7.1.68
IntEnz Enzyme Link: IntEnz 2.7.1.68
MEDLINE Enzyme Link: MEDLINE 2.7.1.68

EC number:2.7.1.68

MSA:

2.7.1.68;
Phylogenetic Tree:

2.7.1.68;
Uniprot:
M-CSA:
RHEA:14425 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:1]-[O;H0;+0:2]-[P;H0;+0:4](=[*:3])(-[*:5])-[*:6].[*:8]-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.Rameh LE, Tolias KF, Duckworth BC, Cantley LC1997 Nov 139367159
Regulation and cellular roles of phosphoinositide 5-kinases.Oude Weernink PA, Schmidt M, Jakobs KH2004 Oct 115464023