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2. Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

ID:

2.7.1.71

Description:

Shikimate kinase.

Prosite:

PDOC00868;

PDB:

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Cath:

1.20.1090.10; 3.20.20.70; 3.30.730.30; 3.40.50.1970; 3.40.50.300;

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PDB	Click once to unfold,double click to fold. 3NWJ; 3N2E; 3HR7; 3MUF; 1ZUI; 1ZUH; 3TRF; 2PT5; 2DFT; 4BQS; 2IYR; 2G1J; 3BAF; 2IYZ; 2IYY; 2IYX; 2IYW; 2IYV; 2IYU; 2IYT; 2IYS; 2IYQ; 2G1K; 2DFN; 1ZYU; 1WE2; 1U8A; 1L4Y; 1L4U; 2SHK; 1SHK; 1E6C; 1KAG;

UniProtKB Enzyme Link:	UniProtKB 2.7.1.71
BRENDA Enzyme Link:	BRENDA 2.7.1.71
KEGG Enzyme Link:	KEGG2.7.1.71
BioCyc Enzyme Link:	BioCyc 2.7.1.71
ExPASy Enzyme Link:	ExPASy2.7.1.71
EC2PDB Enzyme Link:	EC2PDB 2.7.1.71
ExplorEnz Enzyme Link:	ExplorEnz 2.7.1.71
PRIAM enzyme-specific profiles Link:	PRIAM 2.7.1.71
IntEnz Enzyme Link:	IntEnz 2.7.1.71
MEDLINE Enzyme Link:	MEDLINE 2.7.1.71

RHEA:13121	ATP + shikimate = 3-phosphoshikimate + ADP + H(+)
RULE(radius=1)	[:1]-[OH;+0:2].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:7]-[:8]>>[:8]-[OH;+0:7].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:2]-[:1]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
The role of the C8 proton of ATP in the catalysis of shikimate kinase and adenylate kinase.	Kenyon CP, Roth RL	2012 Aug 10	22876783
Biochemical and X-ray crystallographic studies on shikimate kinase: the important structural role of the P-loop lysine.	Krell T, Maclean J, Boam DJ, Cooper A, Resmini M, Brocklehurst K, Kelly SM, Price NC, Lapthorn AJ, Coggins JR	2001 Jun	11369852
Archaeal shikimate kinase, a new member of the GHMP-kinase family.	Daugherty M, Vonstein V, Overbeek R, Osterman A	2001 Jan	11114929