EC number:2.7.1.78
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.1 Phosphotransferases with an alcohol group as acceptor |
| ID: | 2.7.1.78 |
|---|---|
| Description: | Polynucleotide 5'-hydroxyl-kinase. |
| Cath: | 3.40.50.1000; 3.40.50.300; 2.60.200.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.1.78 |
| BRENDA Enzyme Link: | BRENDA 2.7.1.78 |
| KEGG Enzyme Link: | KEGG2.7.1.78 |
| BioCyc Enzyme Link: | BioCyc 2.7.1.78 |
| ExPASy Enzyme Link: | ExPASy2.7.1.78 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.1.78 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.1.78 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.1.78 |
| IntEnz Enzyme Link: | IntEnz 2.7.1.78 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.1.78 |
| RHEA:54580 | 5'-dephospho-(RNA) + ATP = 5'-end-(RNA) + ADP + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. II. Further properties of the 5'-hydroxyl polynucleotide kinase. | Novogrodsky A, Tal M, Traub A, Hurwitz J | 1966 Jun 25 | 4287930 |
| The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. I. Phosphorylation at 5'-hydroxyl termini. | Novogrodsky A, Hurwitz J | 1966 Jun 25 | 4287929 |
| Characterization of a thermostable archaeal polynucleotide kinase homologous to human Clp1. | Jain R, Shuman S | 2009 May | 19299550 |
| RHEA:15669 | 5'-dephospho-(DNA) + ATP = ADP + H(+) + phospho-5'-(DNA) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. II. Further properties of the 5'-hydroxyl polynucleotide kinase. | Novogrodsky A, Tal M, Traub A, Hurwitz J | 1966 Jun 25 | 4287930 |
| The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. I. Phosphorylation at 5'-hydroxyl termini. | Novogrodsky A, Hurwitz J | 1966 Jun 25 | 4287929 |
| Characterization of a thermostable archaeal polynucleotide kinase homologous to human Clp1. | Jain R, Shuman S | 2009 May | 19299550 |