EC number:2.7.1.87

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.1 Phosphotransferases with an alcohol group as acceptor
ID:2.7.1.87
Description:Streptomycin 3''-kinase.
Alternative Name: Streptomycin 3''-phosphotransferase.
Cath: 3.30.200.20; 3.90.1200.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.1.87
BRENDA Enzyme Link: BRENDA 2.7.1.87
KEGG Enzyme Link: KEGG2.7.1.87
BioCyc Enzyme Link: BioCyc 2.7.1.87
ExPASy Enzyme Link: ExPASy2.7.1.87
EC2PDB Enzyme Link: EC2PDB 2.7.1.87
ExplorEnz Enzyme Link: ExplorEnz 2.7.1.87
PRIAM enzyme-specific profiles Link: PRIAM 2.7.1.87
IntEnz Enzyme Link: IntEnz 2.7.1.87
MEDLINE Enzyme Link: MEDLINE 2.7.1.87

EC number:2.7.1.87

MSA:

2.7.1.87;
Phylogenetic Tree:

2.7.1.87;
Uniprot:
M-CSA:
RHEA:18377 ATP + streptomycin = ADP + H(+) + streptomycin 3''-phosphate
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:1]-[O;H0;+0:2]-[P;H0;+0:4](=[*:3])(-[*:5])-[*:6].[*:8]-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
ATP:streptomycin 3"=phosphotransferase.Walker JB, Walker MS197549000
Phosphorylation of streptomycin and dihydrostreptomycin by Streptomyces. Enzymatic synthesis of different diphosphorylated derivatives.Walker JB, Skorvaga M1973 Apr 104121456
A second streptomycin resistance gene from Streptomyces griseus codes for streptomycin-3"-phosphotransferase. Relationships between antibiotic and protein kinases.Heinzel P, Werbitzky O, Distler J, Piepersberg W19882844130