EC number:2.7.1.91

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.1 Phosphotransferases with an alcohol group as acceptor
ID:2.7.1.91
Description:Sphingosine kinase.
Alternative Name: Sphingoid base kinase.
Sphinganine kinase.
Dihydrosphingosine kinase.
Prosite: PDOC50146;
PDB:
PDBScop
2QVL 8024046; 8036425;
2QV7 8024046; 8036425;
2P1R 8022940; 8035320; 8022940; 8035320; 8022940; 8035320; 8022940; 8035320;
2BON 8021181; 8033561; 8021181; 8033561;
2JGR 8021181; 8033561;
 » show all
Cath: 3.40.50.10330; 2.60.200.40;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.1.91
BRENDA Enzyme Link: BRENDA 2.7.1.91
KEGG Enzyme Link: KEGG2.7.1.91
BioCyc Enzyme Link: BioCyc 2.7.1.91
ExPASy Enzyme Link: ExPASy2.7.1.91
EC2PDB Enzyme Link: EC2PDB 2.7.1.91
ExplorEnz Enzyme Link: ExplorEnz 2.7.1.91
PRIAM enzyme-specific profiles Link: PRIAM 2.7.1.91
IntEnz Enzyme Link: IntEnz 2.7.1.91
MEDLINE Enzyme Link: MEDLINE 2.7.1.91

EC number:2.7.1.91

MSA:

2.7.1.91;
Phylogenetic Tree:

2.7.1.91;
Uniprot:
M-CSA:
RHEA:15465 ATP + sphinganine = ADP + H(+) + sphinganine 1-phosphate
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Molecular cloning and functional characterization of murine sphingosine kinase.Kohama T, Olivera A, Edsall L, Nagiec MM, Dickson R, Spiegel S1998 Sep 119726979
1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase.Gijsbers S, Asselberghs S, Herdewijn P, Van Veldhoven PP2002 Jan 3011923095
Functional characterization of human sphingosine kinase-1.Nava VE, Lacana E, Poulton S, Liu H, Sugiura M, Kono K, Milstien S, Kohama T, Spiegel S2000 May 410802064
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S2000 Jun 3010751414
RHEA:33563 4-hydroxysphinganine + ATP = 4-hydroxysphinganine 1-phosphate + ADP + H(+)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S2000 Jun 3010751414
Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids.Kondo N, Ohno Y, Yamagata M, Obara T, Seki N, Kitamura T, Naganuma T, Kihara A2014 Oct 2725345524
The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases.Nagiec MM, Skrzypek M, Nagiec EE, Lester RL, Dickson RC1998 Jul 319677363
RHEA:35847 ATP + sphing-4-enine = ADP + H(+) + sphing-4-enine 1-phosphate
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase.Gijsbers S, Asselberghs S, Herdewijn P, Van Veldhoven PP2002 Jan 3011923095
Functional characterization of human sphingosine kinase-1.Nava VE, Lacana E, Poulton S, Liu H, Sugiura M, Kono K, Milstien S, Kohama T, Spiegel S2000 May 410802064
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S2000 Jun 3010751414
Phosphatidic acid binds and stimulates Arabidopsis sphingosine kinases.Guo L, Mishra G, Taylor K, Wang X2011 Apr 1521330371
Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes.Pitson SM, D'andrea RJ, Vandeleur L, Moretti PA, Xia P, Gamble JR, Vadas MA, Wattenberg BW2000 Sep 110947957
RHEA:51496 a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Molecular basis of sphingosine kinase 1 substrate recognition and catalysis.Wang Z, Min X, Xiao SH, Johnstone S, Romanow W, Meininger D, Xu H, Liu J, Dai J, An S, Thibault S, Walker N2013 May 723602659
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, Maceyka M, Jiang H, Luo C, Kordula T, Milstien S, Spiegel S2010 Jun 2420577214
Functional characterization of human sphingosine kinase-1.Nava VE, Lacana E, Poulton S, Liu H, Sugiura M, Kono K, Milstien S, Kohama T, Spiegel S2000 May 410802064
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S2000 Jun 3010751414
Phosphatidic acid binds and stimulates Arabidopsis sphingosine kinases.Guo L, Mishra G, Taylor K, Wang X2011 Apr 1521330371
The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases.Nagiec MM, Skrzypek M, Nagiec EE, Lester RL, Dickson RC1998 Jul 319677363