EC number:2.7.10.2
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.10 Protein-tyrosine kinases |
| ID: | 2.7.10.2 | ||
|---|---|---|---|
| Description: | Non-specific protein-tyrosine kinase. | ||
| Alternative Name: |
Cytoplasmic protein tyrosine kinase. | ||
| Prosite: | PDOC00100; | ||
| PDB: |
|
||
| Cath: | 1.10.287.110; 1.10.287.160; 1.10.510.10; 1.10.533.10; 1.10.930.10; 1.20.120.260; 1.20.120.330; 1.20.1270.60; 1.20.5.540; 3.20.20.140; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.10.2 |
| BRENDA Enzyme Link: | BRENDA 2.7.10.2 |
| KEGG Enzyme Link: | KEGG2.7.10.2 |
| BioCyc Enzyme Link: | BioCyc 2.7.10.2 |
| ExPASy Enzyme Link: | ExPASy2.7.10.2 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.10.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.10.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.10.2 |
| IntEnz Enzyme Link: | IntEnz 2.7.10.2 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.10.2 |
| RHEA:10596 | ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein] |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. | Iwahara T, Fujimoto J, Wen D, Cupples R, Bucay N, Arakawa T, Mori S, Ratzkin B, Yamamoto T | 1997 Jan 30 | 9053841 |
| Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine. | Ali N, Halfter U, Chua NH | 1994 Dec 16 | 7527390 |
| Src protein-tyrosine kinase structure and regulation. | Roskoski R Jr | 2004 Nov 26 | 15504335 |
| dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila. | Lochhead PA, Sibbet G, Kinstrie R, Cleghon T, Rylatt M, Morrison DK, Cleghon V | 2003 Sep 1 | 12786602 |
| Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo. | Lorén CE, Scully A, Grabbe C, Edeen PT, Thomas J, McKeown M, Hunter T, Palmer RH | 2001 Jun | 11442633 |
| Biochemical characterization and localization of the dual specificity kinase CLK1. | Menegay HJ, Myers MP, Moeslein FM, Landreth GE | 2000 Sep | 10954422 |