EC number:2.7.11.10

Enzyme

Download
EC Tree
     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.11 Protein-serine/threonine kinases
ID:2.7.11.10
Description:I-kappa-B kinase.
Alternative Name: TBK1.
TANK-binding kinase 1.
Inhibitor of NF-kappa-B kinase.
IKK-2.
IKK-1.
IKK.
IKBKB.
IKBKA.
CHUK.
Prosite: PDOC00100;
PDB:
PDBScop
Cath: 1.10.510.10; 1.20.1270.250; 1.20.5.3860; 3.10.20.90;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.11.10
BRENDA Enzyme Link: BRENDA 2.7.11.10
KEGG Enzyme Link: KEGG2.7.11.10
BioCyc Enzyme Link: BioCyc 2.7.11.10
ExPASy Enzyme Link: ExPASy2.7.11.10
EC2PDB Enzyme Link: EC2PDB 2.7.11.10
ExplorEnz Enzyme Link: ExplorEnz 2.7.11.10
PRIAM enzyme-specific profiles Link: PRIAM 2.7.11.10
IntEnz Enzyme Link: IntEnz 2.7.11.10
MEDLINE Enzyme Link: MEDLINE 2.7.11.10

EC number:2.7.11.10

MSA:

2.7.11.10;
Phylogenetic Tree:

2.7.11.10;
Uniprot:
M-CSA:
RHEA:19073 [I-kappa-B protein]-L-serine + ATP = [I-kappa-B protein]-O-phospho-L-serine + ADP + H(+)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, Young DB, Barbosa M, Mann M, Manning A, Rao A1997 Oct 319346484
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M1997 Oct 179346241
Identification and characterization of an IkappaB kinase.Régnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M1997 Jul 259244310
Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation.Viatour P, Merville MP, Bours V, Chariot A2005 Jan15653325