EC number:2.7.11.12
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.11 Protein-serine/threonine kinases |
| ID: | 2.7.11.12 | ||
|---|---|---|---|
| Description: | cGMP-dependent protein kinase. | ||
| Alternative Name: |
PKG II. PKG 1-beta. PKG 1-alpha. PKG. Guanosine 3':5'-cyclic monophosphate-dependent protein kinase. cGMP-dependent protein kinase I-beta. 3':5'-cyclic GMP-dependent protein kinase. | ||
| Prosite: | PDOC00100; | ||
| PDB: |
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| Cath: | 1.20.5.490; 2.60.120.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.11.12 |
| BRENDA Enzyme Link: | BRENDA 2.7.11.12 |
| KEGG Enzyme Link: | KEGG2.7.11.12 |
| BioCyc Enzyme Link: | BioCyc 2.7.11.12 |
| ExPASy Enzyme Link: | ExPASy2.7.11.12 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.11.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.11.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.11.12 |
| IntEnz Enzyme Link: | IntEnz 2.7.11.12 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.11.12 |
EC number:2.7.11.12
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:46608 | ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. | Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA | 1991 May 15 | 1851997 |
| Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. | Coffer PJ, Woodgett JR | 1991 Oct 15 | 1718748 |
| RHEA:17989 | ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. | Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA | 1991 May 15 | 1851997 |
| Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. | Coffer PJ, Woodgett JR | 1991 Oct 15 | 1718748 |