EC number:2.7.11.14
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.11 Protein-serine/threonine kinases |
| ID: | 2.7.11.14 | ||
|---|---|---|---|
| Description: | Rhodopsin kinase. | ||
| Alternative Name: |
RK. Rhodopsin kinase (phosphorylating). Opsin kinase (phosphorylating). Opsin kinase. GPCR kinase 1. G-protein-coupled receptor kinase 1. Cone opsin kinase. | ||
| Prosite: | PDOC00100; | ||
| PDB: |
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| Cath: | 1.10.167.10; 1.10.287.1270; 1.10.510.10; 1.20.5.40; 1.20.5.4070; 3.30.200.20; 1.20.58.1850; 2.30.29.30; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.11.14 |
| BRENDA Enzyme Link: | BRENDA 2.7.11.14 |
| KEGG Enzyme Link: | KEGG2.7.11.14 |
| BioCyc Enzyme Link: | BioCyc 2.7.11.14 |
| ExPASy Enzyme Link: | ExPASy2.7.11.14 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.11.14 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.11.14 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.11.14 |
| IntEnz Enzyme Link: | IntEnz 2.7.11.14 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.11.14 |
EC number:2.7.11.14
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:23356 | [rhodopsin]-L-serine + ATP = [rhodopsin]-O-phospho-L-serine + ADP + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Non-visual GRKs: are we seeing the whole picture? | Willets JM, Challiss RA, Nahorski SR | 2003 Dec | 14654303 |
| Rhodopsin kinase: expression in baculovirus-infected insect cells, and characterization of post-translational modifications. | Cha K, Bruel C, Inglese J, Khorana HG | 1997 Sep 30 | 9380677 |
| Characterization and chromosomal localization of the gene for human rhodopsin kinase. | Khani SC, Abitbol M, Yamamoto S, Maravic-Magovcevic I, Dryja TP | 1996 Aug 1 | 8812493 |
| Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase. | Shichi H, Somers RL | 1978 Oct 10 | 690139 |
| Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase. | Benovic JL, Mayor F Jr, Somers RL, Caron MG, Lefkowitz RJ | 1986 Jun 26-Jul 2 | 3014340 |
| Purification and characterization of rhodopsin kinase. | Palczewski K, McDowell JH, Hargrave PA | 1988 Oct 5 | 2844754 |
| GRK1 and GRK7: unique cellular distribution and widely different activities of opsin phosphorylation in the zebrafish rods and cones. | Wada Y, Sugiyama J, Okano T, Fukada Y | 2006 Aug | 16787417 |
| Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin. | Weller M, Virmaux N, Mandel P | 1975 Jan | 164024 |
| Identification of the autophosphorylation sites in rhodopsin kinase. | Palczewski K, Buczyłko J, Van Hooser P, Carr SA, Huddleston MJ, Crabb JW | 1992 Sep 15 | 1527025 |
| Characterization of human GRK7 as a potential cone opsin kinase. | Chen CK, Zhang K, Church-Kopish J, Huang W, Zhang H, Chen YJ, Frederick JM, Baehr W | 2001 Dec 21 | 11754336 |
| Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. | Chen CK, Burns ME, Spencer M, Niemi GA, Chen J, Hurley JB, Baylor DA, Simon MI | 1999 Mar 30 | 10097103 |