EC number:2.7.11.16
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.11 Protein-serine/threonine kinases |
| ID: | 2.7.11.16 | ||
|---|---|---|---|
| Description: | [G-protein-coupled receptor] kinase. | ||
| Alternative Name: |
GPCRK. GPCR kinase. G protein-coupled receptor kinase. | ||
| Prosite: | PDOC00100; | ||
| PDB: |
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| Cath: | 1.10.167.10; 1.10.287.1270; 1.10.510.10; 1.20.5.40; 1.20.5.4070; 3.30.200.20; 1.20.58.1850; 2.30.29.30; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.11.16 |
| BRENDA Enzyme Link: | BRENDA 2.7.11.16 |
| KEGG Enzyme Link: | KEGG2.7.11.16 |
| BioCyc Enzyme Link: | BioCyc 2.7.11.16 |
| ExPASy Enzyme Link: | ExPASy2.7.11.16 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.11.16 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.11.16 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.11.16 |
| IntEnz Enzyme Link: | IntEnz 2.7.11.16 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.11.16 |
EC number:2.7.11.16
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:12008 | [G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5. | Kunapuli P, Onorato JJ, Hosey MM, Benovic JL | 1994 Jan 14 | 8288567 |
| Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. | Premont RT, Koch WJ, Inglese J, Lefkowitz RJ | 1994 Mar 4 | 8120045 |
| G-protein-coupled receptor phosphorylation: where, when and by whom. | Tobin AB | 2008 Mar | 18193069 |
| [Mechanisms of regulation and function of G-protein coupled receptor kinases]. | Sobierajska K, Fabczak H, Fabczak S | 2005 | 16676577 |
| Non-visual GRKs: are we seeing the whole picture? | Willets JM, Challiss RA, Nahorski SR | 2003 Dec | 14654303 |