EC number:2.7.11.17
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.11 Protein-serine/threonine kinases |
| ID: | 2.7.11.17 | ||
|---|---|---|---|
| Description: | Calcium/calmodulin-dependent protein kinase. | ||
| Alternative Name: |
Microtubule-associated protein 2 kinase. CaMKK-beta. CaMKK-alpha. CaMKIV. CaMKII. CaMKI. CaM-regulated serine/threonine kinase. CAM PKII. CaM kinase II. CaM kinase. Calmodulin-dependent kinase II. Caldesmon kinase (phosphorylating). Caldesmon kinase. Calcium/calmodulin-dependent protein kinase type II. Ca(2+)/calmodulin-dependent protein kinase kinase beta. Ca(2+)/calmodulin-dependent protein kinase kinase. Ca(2+)/calmodulin-dependent protein kinase IV. Ca(2+)/calmodulin-dependent protein kinase II. Ca(2+)/calmodulin-dependent protein kinase 1. Ca(2+)/calmodulin-dependent microtubule-associated protein 2 kinase. | ||
| Prosite: | PDOC00100; | ||
| PDB: |
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| Cath: | 1.10.238.10; 1.10.287.20; 1.10.287.2020; 1.10.510.10; 3.10.450.50; 3.30.200.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.11.17 |
| BRENDA Enzyme Link: | BRENDA 2.7.11.17 |
| KEGG Enzyme Link: | KEGG2.7.11.17 |
| BioCyc Enzyme Link: | BioCyc 2.7.11.17 |
| ExPASy Enzyme Link: | ExPASy2.7.11.17 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.11.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.11.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.11.17 |
| IntEnz Enzyme Link: | IntEnz 2.7.11.17 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.11.17 |
EC number:2.7.11.17
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:46608 | ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. | Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA | 1991 May 15 | 1851997 |
| Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. | Coffer PJ, Woodgett JR | 1991 Oct 15 | 1718748 |
| RHEA:17989 | ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. | Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA | 1991 May 15 | 1851997 |
| Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. | Coffer PJ, Woodgett JR | 1991 Oct 15 | 1718748 |