EC number:2.7.11.18
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.11 Protein-serine/threonine kinases |
| ID: | 2.7.11.18 | ||
|---|---|---|---|
| Description: | [Myosin light-chain] kinase. | ||
| Alternative Name: |
Smooth-muscle-myosin-light-chain kinase. Myosin light-chain kinase (phosphorylating). Myosin light-chain kinase. Myosin light chain protein kinase. Myosin light chain kinase. Myosin kinase. MLCkase. MLCK. Calcium/calmodulin-dependent myosin light chain kinase. [Myosin-light-chain] kinase. | ||
| Prosite: | PDOC00100; | ||
| PDB: |
|
||
| Cath: | 1.10.238.10; 1.10.287.20; 1.10.287.2020; 1.10.510.10; 3.10.450.50; 3.30.200.20; 2.40.155.10; 2.60.40.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.11.18 |
| BRENDA Enzyme Link: | BRENDA 2.7.11.18 |
| KEGG Enzyme Link: | KEGG2.7.11.18 |
| BioCyc Enzyme Link: | BioCyc 2.7.11.18 |
| ExPASy Enzyme Link: | ExPASy2.7.11.18 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.11.18 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.11.18 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.11.18 |
| IntEnz Enzyme Link: | IntEnz 2.7.11.18 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.11.18 |
EC number:2.7.11.18
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:53900 | [myosin light chain]-L-threonine + ATP = [myosin light chain]-O-phospho-L-threonine + ADP + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of a smooth muscle myosin light chain kinase-phosphatase complex. | Sobieszek A, Borkowski J, Babiychuk VS | 1997 Mar 14 | 9054394 |
| [Role of gonorrheal infection in vaginal inflammatory conditions]. | Rzempoluch J, Rzempoluch E, Gebas H, Mańka W | 1977 May-Jun | 897230 |
| Purification and characterization of smooth muscle myosin light chain kinase. | Adelstein RS, Klee CB | 1981 Jul 25 | 6894756 |
| Myosin light-chain kinase, a new enzyme from striated muscle. | Pires E, Perry SV, Thomas MA | 1974 May 1 | 4853304 |
| Characterization of chicken skeletal muscle myosin light chain kinase. Evidence for muscle-specific isozymes. | Nunnally MH, Rybicki SB, Stull JT | 1985 Jan 25 | 3881420 |
| Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase. | Ikebe M, Hartshorne DJ | 1985 Aug 25 | 3839510 |
| The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. | Kamm KE, Stull JT | 1985 | 2988424 |
| Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity. | Hathaway DR, Adelstein RS | 1979 Apr | 156362 |
| Detecting protein kinase recognition modes of calmodulin by residual dipolar couplings in solution NMR. | Mal TK, Skrynnikov NR, Yap KL, Kay LE, Ikura M | 2002 Oct 29 | 12390014 |
| 220- and 130-kDa MLCKs have distinct tissue distributions and intracellular localization patterns. | Blue EK, Goeckeler ZM, Jin Y, Hou L, Dixon SA, Herring BP, Wysolmerski RB, Gallagher PJ | 2002 Mar | 11832329 |
| Differential regulation of alternatively spliced endothelial cell myosin light chain kinase isoforms by p60(Src). | Birukov KG, Csortos C, Marzilli L, Dudek S, Ma SF, Bresnick AR, Verin AD, Cotter RJ, Garcia JG | 2001 Mar 16 | 11113114 |
| Enzyme kinetic characterization of the smooth muscle myosin phosphorylating system: activation by calcium and calmodulin and possible inhibitory mechanisms of antagonists. | Sobieszek A | 1999 May 6 | 10231558 |
| Myosin light chain kinase from skeletal muscle regulates an ATP-dependent interaction between actin and myosin by binding to actin. | Fujita K, Ye LH, Sato M, Okagaki T, Nagamachi Y, Kohama K | 1999 Jan | 10098974 |
| RHEA:22004 | [myosin light chain]-L-serine + ATP = [myosin light chain]-O-phospho-L-serine + ADP + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of a smooth muscle myosin light chain kinase-phosphatase complex. | Sobieszek A, Borkowski J, Babiychuk VS | 1997 Mar 14 | 9054394 |
| [Role of gonorrheal infection in vaginal inflammatory conditions]. | Rzempoluch J, Rzempoluch E, Gebas H, Mańka W | 1977 May-Jun | 897230 |
| Purification and characterization of smooth muscle myosin light chain kinase. | Adelstein RS, Klee CB | 1981 Jul 25 | 6894756 |
| Myosin light-chain kinase, a new enzyme from striated muscle. | Pires E, Perry SV, Thomas MA | 1974 May 1 | 4853304 |
| Characterization of chicken skeletal muscle myosin light chain kinase. Evidence for muscle-specific isozymes. | Nunnally MH, Rybicki SB, Stull JT | 1985 Jan 25 | 3881420 |
| Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase. | Ikebe M, Hartshorne DJ | 1985 Aug 25 | 3839510 |
| The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. | Kamm KE, Stull JT | 1985 | 2988424 |
| Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity. | Hathaway DR, Adelstein RS | 1979 Apr | 156362 |
| Detecting protein kinase recognition modes of calmodulin by residual dipolar couplings in solution NMR. | Mal TK, Skrynnikov NR, Yap KL, Kay LE, Ikura M | 2002 Oct 29 | 12390014 |
| 220- and 130-kDa MLCKs have distinct tissue distributions and intracellular localization patterns. | Blue EK, Goeckeler ZM, Jin Y, Hou L, Dixon SA, Herring BP, Wysolmerski RB, Gallagher PJ | 2002 Mar | 11832329 |
| Differential regulation of alternatively spliced endothelial cell myosin light chain kinase isoforms by p60(Src). | Birukov KG, Csortos C, Marzilli L, Dudek S, Ma SF, Bresnick AR, Verin AD, Cotter RJ, Garcia JG | 2001 Mar 16 | 11113114 |
| Enzyme kinetic characterization of the smooth muscle myosin phosphorylating system: activation by calcium and calmodulin and possible inhibitory mechanisms of antagonists. | Sobieszek A | 1999 May 6 | 10231558 |
| Myosin light chain kinase from skeletal muscle regulates an ATP-dependent interaction between actin and myosin by binding to actin. | Fujita K, Ye LH, Sato M, Okagaki T, Nagamachi Y, Kohama K | 1999 Jan | 10098974 |