EC number:2.7.11.2

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.11 Protein-serine/threonine kinases
ID:2.7.11.2
Description:[Pyruvate dehydrogenase (acetyl-transferring)] kinase.
Alternative Name: Pyruvate dehydrogenase kinase (phosphorylating).
Pyruvate dehydrogenase kinase.
PDK.
PDHK.
PDH kinase.
Prosite: PDOC50109;
PDB:
PDBScop
3CRK 8030722; 8043101; 8024773; 8024776; 8037152; 8037155; 8030722; 8043101; 8024773; 8024776; 8037152; 8037155;
2CH4 8026481; 8038860; 8021284; 8029611; 8033664; 8041990; 8026481; 8038860; 8021284; 8029611; 8033664; 8041990;
3UR1 8026481; 8038860; 8021284; 8029611; 8033664; 8041990;
1R62 8026376; 8038755;
3CRL 8024773; 8024776; 8037152; 8037155; 8030722; 8043101; 8024773; 8024776; 8037152; 8037155; 8030722; 8043101;
 » show all
Cath: 1.20.140.20; 3.30.565.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.11.2
BRENDA Enzyme Link: BRENDA 2.7.11.2
KEGG Enzyme Link: KEGG2.7.11.2
BioCyc Enzyme Link: BioCyc 2.7.11.2
ExPASy Enzyme Link: ExPASy2.7.11.2
EC2PDB Enzyme Link: EC2PDB 2.7.11.2
ExplorEnz Enzyme Link: ExplorEnz 2.7.11.2
PRIAM enzyme-specific profiles Link: PRIAM 2.7.11.2
IntEnz Enzyme Link: IntEnz 2.7.11.2
MEDLINE Enzyme Link: MEDLINE 2.7.11.2

EC number:2.7.11.2

MSA:

2.7.11.2;
Phylogenetic Tree:

2.7.11.2;
Uniprot:
M-CSA:
RHEA:23052 [pyruvate dehydrogenase E1 alpha subunit]-L-serine + ATP = [pyruvate dehydrogenase E1 alpha subunit]-O-phospho-L-serine + ADP + H(+)
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart.Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ1972 Feb4401694
Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.Kato M, Li J, Chuang JL, Chuang DT2007 Aug17683942
Analysis of the catalytic mechanism of pyruvate dehydrogenase kinase.Tovar-Méndez A, Hirani TA, Miernyk JA, Randall DD2005 Feb 115629119
Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP.Bao H, Kasten SA, Yan X, Hiromasa Y, Roche TE2004 Oct 2615491151
Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1.Roche TE, Hiromasa Y, Turkan A, Gong X, Peng T, Yan X, Kasten SA, Bao H, Dong J2003 Mar12631265
Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.Korotchkina LG, Patel MS2001 Oct 511486000