EC number:2.7.11.24

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.11 Protein-serine/threonine kinases
ID:2.7.11.24
Description:Mitogen-activated protein kinase.
Alternative Name: Stress-activated protein kinase.
SAPK.
Myelin basic protein kinase.
Microtubule-associated protein kinase.
Microtubule-associated protein 2 kinase.
MBP kinase II.
MBP kinase I.
MAPK.
MAP kinase.
JNK.
Extracellular signal-regulated kinase.
ERK.
C-Jun N-terminal kinase.
Prosite: PDOC01049; PDOC00100;
PDB:
PDBScop
4IZ5 8089623; 8089624; 8089623; 8089624; 8024256; 8036635; 8089623; 8089624; 8024256; 8036635; 8089623; 8089624; 8024256; 8036635; 8024256; 8036635;
3NPC 8079598; 8079599; 8079598; 8079599;
3E7O 8079598; 8079599; 8079598; 8079599;
5AWM 8079596; 8079597;
4MYG 8079592; 8079593; 8079592; 8079593;
 » show all
Cath: 1.10.287.4220; 1.10.510.10; 3.30.200.20; 3.10.20.90;

3D structure

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PDB

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4IZ5; 3NPC; 3E7O; 5AWM; 4MYG; 5EKO; 5EKN; 4YNO; 4EYM; 4EYJ; 3COI; 3GC9; 3GC8; 3GP0; 6DTL; 5CI6; 6GES; 4QTB; 2ZOQ; 4IC8; 4IC7; 6HKN; 6HKM; 5O7I; 5BYZ; 5BYY; 4ZSL; 4ZSJ; 4ZSG; 4B99; 2FA2; 2F49; 2F9G; 2B9J; 2B9I; 2B9H; 2B9F; 4TYH; 2OZA; 2ONL; 4YR8; 4UX9; 5LW1; 3O2M; 3O17; 2NO3; 2H96; 2GMX; 2G01; 6F5E; 4QTD; 4L7F; 4IZY; 4HYS; 4G1W; 4E73; 4AWI; 3VUG; 3VUD; 3V3V; 3PZE; 3ELJ; 2XS0; 2XRW; 1UKI; 6EMH; 6EQ9; 4X21; 4H3B; 3V6S; 3V6R; 6EKD; 4Z9L; 4Y5H; 4Y46; 4WHZ; 4W4Y; 4W4X; 4W4W; 4W4V; 4U79; 4KKH; 4KKG; 4KKE; 4H39; 4H36; 3TTJ; 3TTI; 3RTP; 3PTG; 3OY1; 3OXI; 3G9N; 3G9L; 3G90; 3DA6; 3CGO; 3CGF; 2ZDU; 2ZDT; 2WAJ; 2P33; 2OK1; 2O2U; 2O0U; 2EXC; 2B1P; 1PMV; 1PMU; 1PMN; 1JNK; 4N4S; 3ZUV; 3C9W; 2FYS; 6DCG; 6CPW; 5UMO; 5U6I; 5KE0; 5HD7; 5HD4; 4S34; 4S33; 4S32; 4S31; 4S30; 4S2Z; 4QYY; 4I5H; 4ERK; 3ZU7; 3R63; 3O71; 3ERK; 2Z7L; 2GPH; 2ERK; 1GOL; 1ERK; 4IZA; 4IZ7; 4XJ0; 4QPA; 4QP8; 4QP7; 4QP6; 4QP4; 4QP3; 4QP2; 4QP1; 4H3P; 6G54; 6D5Y; 5V62; 5V61; 5V60; 5NHV; 5NHP; 5NHO; 5NHL; 5NHJ; 5NHH; 5K4I; 5BVF; 5BVE; 5BVD; 5BUJ; 5BUI; 5BUE; 5AX3; 4QTE; 4QTA; 4QP9; 4O6E; 4H3Q; 4FV6; 4FMQ; 3TEI; 3I60; 3I5Z; 2Y9Q; 2OJJ; 2OJI; 2OJG; 1WZY; 1TVO; 1CM8; 5NZZ; 4LOQ; 4LOP; 5UOJ; 5O90; 5LAR; 4LOO; 4KA3; 3TG1; 3PY3; 3P7C; 3P7B; 3P7A; 3P79; 3P78; 3P5K; 3P4K; 2PUU; 2GTN; 2GTM; 2GHM; 2GHL; 2EWA; 1YWR; 1YW2; 1LEZ; 1LEW; 4KIQ; 4KIN; 3DS6; 5ETA; 4KIP; 3MVM; 3MVL; 3HV5; 3HV4; 3GCU; 2OKR; 6M9L; 6M95; 6HWV; 6HWU; 6HWT; 6ANL; 5XYY; 5XYX; 5WJJ; 5TCO; 5TBE; 5OMH; 5OMG; 5O8V; 5O8U; 5N68; 5N67; 5N66; 5N65; 5N64; 5N63; 5MZ3; 5MTY; 5MTX; 5ML5; 5ETI; 5ETF; 5ETC; 4ZTH; 4L8M; 4GEO; 4FA2; 4F9Y; 4F9W; 4EWQ; 4EHV; 4EH9; 4EH8; 4EH7; 4EH6; 4EH5; 4EH4; 4EH3; 4EH2; 4E8A; 4E6C; 4E6A; 4E5B; 4E5A; 4DLJ; 4DLI; 4AAC; 4AA4; 4AA0; 4A9Y; 3ZYA; 3ZSI; 3ZSH; 3ZSG; 3ZS5; 3UVR; 3UVQ; 3UVP; 3U8W; 3S4Q; 3S3I; 3ROC; 3RIN; 3QUE; 3QUD; 3PG3; 3OEF; 3ODZ; 3ODY; 3OD6; 3OCG; 3OC1; 3OBJ; 3OBG; 3O8U; 3O8T; 3O8P; 3NWW; 3NNX; 3NNW; 3NNV; 3NNU; 3NEW; 3MW1; 3MPT; 3MPA; 3MH3; 3MH2; 3MH1; 3MH0; 3MGY; 3LHJ; 3LFF; 3LFE; 3LFD; 3LFC; 3LFB; 3LFA; 3L8X; 3L8S; 3KQ7; 3KF7; 3K3J; 3K3I; 3IW8; 3IW7; 3IW6; 3IW5; 3ITZ; 3HVC; 3HV7; 3HV6; 3HV3; 3HUC; 3HUB; 3HRB; 3HP5; 3HP2; 3HLL; 3HL7; 3HEG; 3HEC; 3HA8; 3GI3; 3GFE; 3GCV; 3GCS; 3GCQ; 3GCP; 3GC7; 3FSK; 3FSF; 3FMN; 3FMM; 3FML; 3FMK; 3FMJ; 3FMH; 3FLZ; 3FLY; 3FLW; 3FLS; 3FLQ; 3FLN; 3FL4; 3FKO; 3FKN; 3FKL; 3FI4; 3FC1; 3DT1; 3D7Z; 3CTQ; 3C5U; 3BX5; 3BV3; 3BV2; 2ZB1; 2ZB0; 2ZAZ; 2YIX; 2YIW; 2YIS; 2Y8O; 2RG6; 2RG5; 2QD9; 2NPQ; 2LGC; 2I0H; 2GFS; 2FST; 2FSO; 2FSM; 2FSL; 2BAK; 2BAJ; 1ZZL; 1ZZ2; 1ZYJ; 1YQJ; 1WFC; 1WBW; 1WBV; 1WBT; 1WBS; 1WBO; 1WBN; 1W84; 1W83; 1W82; 1W7H; 1R3C; 1R39; 1OZ1; 1OVE; 1OUY; 1OUK; 1M7Q; 1KV2; 1KV1; 1IAN; 1DI9; 1BMK; 1BL7; 1BL6; 1A9U; 4NIF; 4HYU; 3W55; 1UKH;

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.11.24
BRENDA Enzyme Link: BRENDA 2.7.11.24
KEGG Enzyme Link: KEGG2.7.11.24
BioCyc Enzyme Link: BioCyc 2.7.11.24
ExPASy Enzyme Link: ExPASy2.7.11.24
EC2PDB Enzyme Link: EC2PDB 2.7.11.24
ExplorEnz Enzyme Link: ExplorEnz 2.7.11.24
PRIAM enzyme-specific profiles Link: PRIAM 2.7.11.24
IntEnz Enzyme Link: IntEnz 2.7.11.24
MEDLINE Enzyme Link: MEDLINE 2.7.11.24

EC number:2.7.11.24

MSA:

2.7.11.24;
Phylogenetic Tree:

2.7.11.24;
Uniprot:
M-CSA:
RHEA:46608 ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA1991 May 151851997
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families.Coffer PJ, Woodgett JR1991 Oct 151718748
RHEA:17989 ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA1991 May 151851997
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families.Coffer PJ, Woodgett JR1991 Oct 151718748