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2. Transferases

2.7 Transferring phosphorus-containing groups

2.7.11 Protein-serine/threonine kinases

ID:

2.7.11.25

Description:

Mitogen-activated protein kinase kinase kinase.

Alternative Name:

MLTK.
MLK-like mitogen-activated protein triple kinase.
MEKK.
MEK kinase.
MAPKKK.
MAP3K.
MAP kinase kinase kinase.

Prosite:

PDOC00100;

PDB:

PDB	Scop

Cath:

1.10.150.50; 1.10.510.10; 3.30.200.20; 2.30.30.40; 3.10.20.90;

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UniProtKB Enzyme Link:	UniProtKB 2.7.11.25
BRENDA Enzyme Link:	BRENDA 2.7.11.25
KEGG Enzyme Link:	KEGG2.7.11.25
BioCyc Enzyme Link:	BioCyc 2.7.11.25
ExPASy Enzyme Link:	ExPASy2.7.11.25
EC2PDB Enzyme Link:	EC2PDB 2.7.11.25
ExplorEnz Enzyme Link:	ExplorEnz 2.7.11.25
PRIAM enzyme-specific profiles Link:	PRIAM 2.7.11.25
IntEnz Enzyme Link:	IntEnz 2.7.11.25
MEDLINE Enzyme Link:	MEDLINE 2.7.11.25

RHEA:46608	ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
RULE(radius=1)	[:1]-[OH;+0:2].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:7]-[:8]>>[:8]-[OH;+0:7].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:2]-[:1]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.	Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA	1991 May 15	1851997
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families.	Coffer PJ, Woodgett JR	1991 Oct 15	1718748

RHEA:17989	ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
RULE(radius=1)	[:1]-[OH;+0:2].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:7]-[:8]>>[:8]-[OH;+0:7].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:2]-[:1]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.	Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA	1991 May 15	1851997
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families.	Coffer PJ, Woodgett JR	1991 Oct 15	1718748