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2. Transferases

2.7 Transferring phosphorus-containing groups

2.7.11 Protein-serine/threonine kinases

ID:

2.7.11.26

Description:

[Tau protein] kinase.

Alternative Name:

TTK.
TPK.
Tau-tubulin kinase.
Tau kinase.
Protein tau kinase.
GSK.
Glycogen synthase kinase-3-beta.
[Tau-protein] kinase.

Prosite:

PDOC00100;

PDB:

PDB	Scop

Cath:

1.10.238.10; 1.10.287.20; 1.10.287.2020; 1.10.510.10; 1.10.8.10; 3.10.450.50; 3.30.200.20; 3.30.310.80;

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UniProtKB Enzyme Link:	UniProtKB 2.7.11.26
BRENDA Enzyme Link:	BRENDA 2.7.11.26
KEGG Enzyme Link:	KEGG2.7.11.26
BioCyc Enzyme Link:	BioCyc 2.7.11.26
ExPASy Enzyme Link:	ExPASy2.7.11.26
EC2PDB Enzyme Link:	EC2PDB 2.7.11.26
ExplorEnz Enzyme Link:	ExplorEnz 2.7.11.26
PRIAM enzyme-specific profiles Link:	PRIAM 2.7.11.26
IntEnz Enzyme Link:	IntEnz 2.7.11.26
MEDLINE Enzyme Link:	MEDLINE 2.7.11.26

RHEA:53904	[tau protein]-L-threonine + ATP = [tau protein]-O-phospho-L-threonine + ADP + H(+)
RULE(radius=1)	[:1]-[OH;+0:2].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:7]-[:8]>>[:8]-[OH;+0:7].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:2]-[:1]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells.	Michel G, Mercken M, Murayama M, Noguchi K, Ishiguro K, Imahori K, Takashima A	1998 Apr 10	9565682
A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau.	Ishiguro K, Ihara Y, Uchida T, Imahori K	1988 Sep	2467901
Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.	Yoshida H, Goedert M	2012 Jan	21985311
AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure.	Thornton C, Bright NJ, Sastre M, Muckett PJ, Carling D	2011 Mar 15	21204788
Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry.	Lund ET, McKenna R, Evans DB, Sharma SK, Mathews WR	2001 Feb	11181841
Expression, purification and crystallization of human tau-protein kinase I/glycogen synthase kinase-3beta.	Aoki M, Iwamoto-Sugai M, Sugiura I, Sasaki C, Hasegawa T, Okumura C, Sugio S, Kohno T, Matsuzaki T	2000 Nov	11053853

RHEA:12801	[tau protein]-L-serine + ATP = [tau protein]-O-phospho-L-serine + ADP + H(+)
RULE(radius=1)	[:1]-[OH;+0:2].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:7]-[:8]>>[:8]-[OH;+0:7].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:2]-[:1]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells.	Michel G, Mercken M, Murayama M, Noguchi K, Ishiguro K, Imahori K, Takashima A	1998 Apr 10	9565682
A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau.	Ishiguro K, Ihara Y, Uchida T, Imahori K	1988 Sep	2467901
Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.	Yoshida H, Goedert M	2012 Jan	21985311
AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure.	Thornton C, Bright NJ, Sastre M, Muckett PJ, Carling D	2011 Mar 15	21204788
Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry.	Lund ET, McKenna R, Evans DB, Sharma SK, Mathews WR	2001 Feb	11181841
Expression, purification and crystallization of human tau-protein kinase I/glycogen synthase kinase-3beta.	Aoki M, Iwamoto-Sugai M, Sugiura I, Sasaki C, Hasegawa T, Okumura C, Sugio S, Kohno T, Matsuzaki T	2000 Nov	11053853