EC number:2.7.11.30
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.11 Protein-serine/threonine kinases |
| ID: | 2.7.11.30 | ||
|---|---|---|---|
| Description: | Receptor protein serine/threonine kinase. | ||
| Alternative Name: |
TGF-beta kinase. Receptor type II serine/threonine protein kinase. Receptor type I serine/threonine protein kinase. Receptor serine/threonine protein kinase. Activin receptor kinase. | ||
| Prosite: | PDOC00100; | ||
| PDB: |
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| Cath: | 1.10.510.10; 3.30.200.20; 2.10.60.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.11.30 |
| BRENDA Enzyme Link: | BRENDA 2.7.11.30 |
| KEGG Enzyme Link: | KEGG2.7.11.30 |
| BioCyc Enzyme Link: | BioCyc 2.7.11.30 |
| ExPASy Enzyme Link: | ExPASy2.7.11.30 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.11.30 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.11.30 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.11.30 |
| IntEnz Enzyme Link: | IntEnz 2.7.11.30 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.11.30 |
EC number:2.7.11.30
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:44880 | [receptor-protein]-L-threonine + ATP = [receptor-protein]-O-phospho-L-threonine + ADP + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of functional domains within Smad4/DPC4. | de Caestecker MP, Hemmati P, Larisch-Bloch S, Ajmera R, Roberts AB, Lechleider RJ | 1997 May 23 | 9153220 |
| Mechanism of activation of the TGF-beta receptor. | Wrana JL, Attisano L, Wieser R, Ventura F, Massagué J | 1994 Aug 4 | 8047140 |
| Controlling TGF-beta signaling. | Massagué J, Chen YG | 2000 Mar 15 | 10733523 |
| RHEA:18673 | [receptor-protein]-L-serine + ATP = [receptor-protein]-O-phospho-L-serine + ADP + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of functional domains within Smad4/DPC4. | de Caestecker MP, Hemmati P, Larisch-Bloch S, Ajmera R, Roberts AB, Lechleider RJ | 1997 May 23 | 9153220 |
| Mechanism of activation of the TGF-beta receptor. | Wrana JL, Attisano L, Wieser R, Ventura F, Massagué J | 1994 Aug 4 | 8047140 |
| Controlling TGF-beta signaling. | Massagué J, Chen YG | 2000 Mar 15 | 10733523 |