EC number:2.7.11.31
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.11 Protein-serine/threonine kinases |
| ID: | 2.7.11.31 |
|---|---|
| Description: | [Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase. |
| Alternative Name: |
Reductase kinase. Hydroxymethylglutaryl-CoA reductase kinase. Hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating). Hydroxymethylglutaryl coenzyme A reductase kinase. HMG-CoA reductase kinase. Beta-hydroxy-beta-methylglutaryl-CoA reductase kinase. AMPK. AMP-activated protein kinase. [Hydroxymethylglutaryl-CoA reductase (NADPH(2))] kinase. 3-hydroxy-3-methylglutaryl-CoA reductase kinase. 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase. |
| Cath: | 1.10.3270.10; 1.10.510.10; 1.10.8.10; 3.30.200.20; 3.30.310.80; 3.30.70.420; 3.60.21.10; 3.90.770.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.11.31 |
| BRENDA Enzyme Link: | BRENDA 2.7.11.31 |
| KEGG Enzyme Link: | KEGG2.7.11.31 |
| BioCyc Enzyme Link: | BioCyc 2.7.11.31 |
| ExPASy Enzyme Link: | ExPASy2.7.11.31 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.11.31 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.11.31 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.11.31 |
| IntEnz Enzyme Link: | IntEnz 2.7.11.31 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.11.31 |
EC number:2.7.11.31
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:23172 | [3-hydroxy-3-methylglutaryl-coenzyme A reductase]-L-serine + ATP = [3-hydroxy-3-methylglutaryl-coenzyme A reductase]-O-phospho-L-serine + ADP + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase. | Crute BE, Seefeld K, Gamble J, Kemp BE, Witters LA | 1998 Dec 25 | 9857077 |
| Specificity determinants for the AMP-activated protein kinase and its plant homologue analysed using synthetic peptides. | Weekes J, Ball KL, Caudwell FB, Hardie DG | 1993 Nov 22 | 7902296 |
| Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation. | Ingebritsen TS, Lee HS, Parker RA, Gibson DM | 1978 Apr 28 | 666819 |
| Allosteric activation of rat liver microsomal [hydroxymethylglutaryl-CoA reductase (NADPH)]kinase by nucleoside phosphates. | Ferrer A, Caelles C, Massot N, Hegardt FG | 1987 Mar | 3689494 |
| 3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation. | Beg ZH, Stonik JA, Brewer HB Jr | 1978 Aug | 278983 |
| Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver. | Clarke PR, Hardie DG | 1990 Aug | 2369897 |
| Reversible modulation of liver hydroxymethylglutaryl CoA reductase. | Gibson DM, Ingebritsen TS | 1978 Dec 31 | 216867 |
| The regulation of AMP-activated protein kinase by phosphorylation. | Stein SC, Woods A, Jones NA, Davison MD, Carling D | 2000 Feb 1 | 10642499 |