EC number:2.7.11.5
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.11 Protein-serine/threonine kinases |
| ID: | 2.7.11.5 |
|---|---|
| Description: | [Isocitrate dehydrogenase (NADP(+))] kinase. |
| Alternative Name: |
Isocitrate dehydrogenase kinase/phosphatase. Isocitrate dehydrogenase kinase (phosphorylating). Isocitrate dehydrogenase kinase. IDHK/P. IDH-K/P. IDH kinase/phosphatase. IDH kinase. ICDH kinase/phosphatase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.11.5 |
| BRENDA Enzyme Link: | BRENDA 2.7.11.5 |
| KEGG Enzyme Link: | KEGG2.7.11.5 |
| BioCyc Enzyme Link: | BioCyc 2.7.11.5 |
| ExPASy Enzyme Link: | ExPASy2.7.11.5 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.11.5 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.11.5 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.11.5 |
| IntEnz Enzyme Link: | IntEnz 2.7.11.5 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.11.5 |
| RHEA:43540 | [isocitrate dehydrogenase]-L-serine + ATP = [isocitrate dehydrogenase]-O-phospho-L-serine + ADP + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Isocitrate dehydrogenase kinase/phosphatase. Kinetic characteristics of the wild-type and two mutant proteins. | Miller SP, Karschnia EJ, Ikeda TP, LaPorte DC | 1996 Aug 9 | 8702587 |
| Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase. | Zheng J, Jia Z | 2010 Jun 17 | 20505668 |
| Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1.55 A. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase. | Singh SK, Matsuno K, LaPorte DC, Banaszak LJ | 2001 Jul 13 | 11290745 |
| The "catalytic" triad of isocitrate dehydrogenase kinase/phosphatase from E. coli and its relationship with that found in eukaryotic protein kinases. | Oudot C, Cortay JC, Blanchet C, Laporte DC, Di Pietro A, Cozzone AJ, Jault JM | 2001 Mar 13 | 11258918 |