EC number:2.7.11.8
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.11 Protein-serine/threonine kinases |
| ID: | 2.7.11.8 |
|---|---|
| Description: | Fas-activated serine/threonine kinase. |
| Alternative Name: |
FASTK. FAST. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.11.8 |
| BRENDA Enzyme Link: | BRENDA 2.7.11.8 |
| KEGG Enzyme Link: | KEGG2.7.11.8 |
| BioCyc Enzyme Link: | BioCyc 2.7.11.8 |
| ExPASy Enzyme Link: | ExPASy2.7.11.8 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.11.8 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.11.8 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.11.8 |
| IntEnz Enzyme Link: | IntEnz 2.7.11.8 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.11.8 |
| RHEA:53920 | [Fas-activated protein]-L-threonine + ATP = [Fas-activated protein]-O-phospho-L-threonine + ADP + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. | Tian Q, Taupin J, Elledge S, Robertson M, Anderson P | 1995 Sep 1 | 7544399 |
| FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. | Li W, Simarro M, Kedersha N, Anderson P | 2004 Dec | 15572676 |
| RHEA:15881 | [Fas-activated protein]-L-serine + ATP = [Fas-activated protein]-O-phospho-L-serine + ADP + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. | Tian Q, Taupin J, Elledge S, Robertson M, Anderson P | 1995 Sep 1 | 7544399 |
| FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. | Li W, Simarro M, Kedersha N, Anderson P | 2004 Dec | 15572676 |