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2. Transferases

2.7 Transferring phosphorus-containing groups

2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)

ID:

2.7.12.2

Description:

Mitogen-activated protein kinase kinase.

Alternative Name:

MKK.
MEK.
MAPKK.
MAP2K.
MAP kinase kinase.

Prosite:

PDOC00100;

PDB:

PDB	Scop

Cath:

1.10.150.50; 1.10.287.4220; 1.10.510.10; 3.30.200.20; 2.30.30.40; 3.10.20.90;

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UniProtKB Enzyme Link:	UniProtKB 2.7.12.2
BRENDA Enzyme Link:	BRENDA 2.7.12.2
KEGG Enzyme Link:	KEGG2.7.12.2
BioCyc Enzyme Link:	BioCyc 2.7.12.2
ExPASy Enzyme Link:	ExPASy2.7.12.2
EC2PDB Enzyme Link:	EC2PDB 2.7.12.2
ExplorEnz Enzyme Link:	ExplorEnz 2.7.12.2
PRIAM enzyme-specific profiles Link:	PRIAM 2.7.12.2
IntEnz Enzyme Link:	IntEnz 2.7.12.2
MEDLINE Enzyme Link:	MEDLINE 2.7.12.2

RHEA:46608	ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
RULE(radius=1)	[:1]-[OH;+0:2].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:7]-[:8]>>[:8]-[OH;+0:7].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:2]-[:1]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.	Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA	1991 May 15	1851997
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families.	Coffer PJ, Woodgett JR	1991 Oct 15	1718748

RHEA:17989	ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
RULE(radius=1)	[:1]-[OH;+0:2].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:7]-[:8]>>[:8]-[OH;+0:7].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:2]-[:1]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.	Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA	1991 May 15	1851997
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families.	Coffer PJ, Woodgett JR	1991 Oct 15	1718748

RHEA:10596	ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]
RULE(radius=1)	[:1]-[OH;+0:2].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:7]-[:8]>>[:8]-[OH;+0:7].[:3]=[P;H0;+0:4](-[:5])(-[:6])-[O;H0;+0:2]-[:1]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system.	Iwahara T, Fujimoto J, Wen D, Cupples R, Bucay N, Arakawa T, Mori S, Ratzkin B, Yamamoto T	1997 Jan 30	9053841
Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine.	Ali N, Halfter U, Chua NH	1994 Dec 16	7527390
Src protein-tyrosine kinase structure and regulation.	Roskoski R Jr	2004 Nov 26	15504335
dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila.	Lochhead PA, Sibbet G, Kinstrie R, Cleghon T, Rylatt M, Morrison DK, Cleghon V	2003 Sep 1	12786602
Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo.	Lorén CE, Scully A, Grabbe C, Edeen PT, Thomas J, McKeown M, Hunter T, Palmer RH	2001 Jun	11442633
Biochemical characterization and localization of the dual specificity kinase CLK1.	Menegay HJ, Myers MP, Moeslein FM, Landreth GE	2000 Sep	10954422