EC number:2.7.4.2

Enzyme

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EC Tree
     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.4 Phosphotransferases with a phosphate group as acceptor
ID:2.7.4.2
Description:Phosphomevalonate kinase.
Prosite: PDOC00545;
PDB:
PDBScop
Cath: 3.30.230.10; 3.30.70.890; 3.40.50.300;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.4.2
BRENDA Enzyme Link: BRENDA 2.7.4.2
KEGG Enzyme Link: KEGG2.7.4.2
BioCyc Enzyme Link: BioCyc 2.7.4.2
ExPASy Enzyme Link: ExPASy2.7.4.2
EC2PDB Enzyme Link: EC2PDB 2.7.4.2
ExplorEnz Enzyme Link: ExplorEnz 2.7.4.2
PRIAM enzyme-specific profiles Link: PRIAM 2.7.4.2
IntEnz Enzyme Link: IntEnz 2.7.4.2
MEDLINE Enzyme Link: MEDLINE 2.7.4.2

EC number:2.7.4.2

MSA:

2.7.4.2;
Phylogenetic Tree:

2.7.4.2;
Uniprot:
M-CSA:
RHEA:16341 (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.Hinson DD, Chambliss KL, Toth MJ, Tanaka RD, Gibson KM1997 Nov9392419
Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence.Chambliss KL, Slaughter CA, Schreiner R, Hoffmann GF, Gibson KM1996 Jul 198663599
Phosphomevalonate kinase from pig liver.Eyzaguirre J, Bazaes S19852991707
Biochemical evidence supporting the presence of the classical mevalonate pathway in the thermoacidophilic archaeon Sulfolobus solfataricus.Nishimura H, Azami Y, Miyagawa M, Hashimoto C, Yoshimura T, Hemmi H2013 May23378249
Functional evaluation of conserved basic residues in human phosphomevalonate kinase.Herdendorf TJ, Miziorko HM2007 Oct 2317902708
Pig liver phosphomevalonate kinase: kinetic mechanism.Eyzaguirre J, Valdebenito D, Cardemil E2006 Oct 1516973124
Phosphomevalonate kinase: functional investigation of the recombinant human enzyme.Herdendorf TJ, Miziorko HM2006 Mar 1416519518