EC number:2.7.4.21
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.4 Phosphotransferases with a phosphate group as acceptor |
| ID: | 2.7.4.21 |
|---|---|
| Description: | Inositol-hexakisphosphate kinase. |
| Alternative Name: |
IP6K. ATP:1D-myo-inositol-hexakisphosphate phosphotransferase. |
| Cath: | 3.30.470.10; 3.30.470.100; 3.40.50.11950; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.4.21 |
| BRENDA Enzyme Link: | BRENDA 2.7.4.21 |
| KEGG Enzyme Link: | KEGG2.7.4.21 |
| BioCyc Enzyme Link: | BioCyc 2.7.4.21 |
| ExPASy Enzyme Link: | ExPASy2.7.4.21 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.4.21 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.4.21 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.4.21 |
| IntEnz Enzyme Link: | IntEnz 2.7.4.21 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.4.21 |
| RHEA:37467 | 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8].[H+;H0:9]>>[*:1]-[O;H0;+0:2]-[P;H0;+0:4](=[*:3])(-[*:5])-[*:6].[*:8]-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. | Wang H, Falck JR, Hall TM, Shears SB | 2011 Nov 27 | 22119861 |
| Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. | Lin H, Fridy PC, Ribeiro AA, Choi JH, Barma DK, Vogel G, Falck JR, Shears SB, York JD, Mayr GW | 2009 Jan 16 | 18981179 |
| Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. | Choi JH, Williams J, Cho J, Falck JR, Shears SB | 2007 Oct 19 | 17702752 |
| Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. | Fridy PC, Otto JC, Dollins DE, York JD | 2007 Oct 19 | 17690096 |
| A conserved family of enzymes that phosphorylate inositol hexakisphosphate. | Mulugu S, Bai W, Fridy PC, Bastidas RJ, Otto JC, Dollins DE, Haystead TA, Ribeiro AA, York JD | 2007 Apr 6 | 17412958 |
| Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. | Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH | 1999 Nov 18 | 10574768 |
| Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells. | Albert C, Safrany ST, Bembenek ME, Reddy KM, Reddy K, Falck J, Bröcker M, Shears SB, Mayr GW | 1997 Oct 15 | 9359429 |
| PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase. | Schell MJ, Letcher AJ, Brearley CA, Biber J, Murer H, Irvine RF | 1999 Nov 19 | 10567691 |
| RHEA:12793 | 1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:1]-[O;H0;+0:2]-[P;H0;+0:4](=[*:3])(-[*:5])-[*:6].[*:8]-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain. | Gokhale NA, Zaremba A, Shears SB | 2011 Mar 15 | 21222653 |
| Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. | Lin H, Fridy PC, Ribeiro AA, Choi JH, Barma DK, Vogel G, Falck JR, Shears SB, York JD, Mayr GW | 2009 Jan 16 | 18981179 |
| Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups. | Draskovic P, Saiardi A, Bhandari R, Burton A, Ilc G, Kovacevic M, Snyder SH, Podobnik M | 2008 Mar | 18355727 |
| Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. | Choi JH, Williams J, Cho J, Falck JR, Shears SB | 2007 Oct 19 | 17702752 |
| Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. | Fridy PC, Otto JC, Dollins DE, York JD | 2007 Oct 19 | 17690096 |
| A conserved family of enzymes that phosphorylate inositol hexakisphosphate. | Mulugu S, Bai W, Fridy PC, Bastidas RJ, Otto JC, Dollins DE, Haystead TA, Ribeiro AA, York JD | 2007 Apr 6 | 17412958 |
| Identification and characterization of a novel inositol hexakisphosphate kinase. | Saiardi A, Nagata E, Luo HR, Snowman AM, Snyder SH | 2001 Oct 19 | 11502751 |