EC number:2.7.4.24
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.4 Phosphotransferases with a phosphate group as acceptor |
| ID: | 2.7.4.24 |
|---|---|
| Description: | Diphosphoinositol-pentakisphosphate kinase. |
| Alternative Name: |
PP-IP(5) kinase. PP-InsP(5) kinase. Diphosphoinositol pentakisphosphate kinase. |
| Cath: | 3.30.470.10; 3.30.470.100; 3.40.50.11950; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.4.24 |
| BRENDA Enzyme Link: | BRENDA 2.7.4.24 |
| KEGG Enzyme Link: | KEGG2.7.4.24 |
| BioCyc Enzyme Link: | BioCyc 2.7.4.24 |
| ExPASy Enzyme Link: | ExPASy2.7.4.24 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.4.24 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.4.24 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.4.24 |
| IntEnz Enzyme Link: | IntEnz 2.7.4.24 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.4.24 |
| RHEA:37459 | 1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:1]-[O;H0;+0:2]-[P;H0;+0:4](=[*:3])(-[*:5])-[*:6].[*:8]-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. | Wang H, Falck JR, Hall TM, Shears SB | 2011 Nov 27 | 22119861 |
| Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. | Lin H, Fridy PC, Ribeiro AA, Choi JH, Barma DK, Vogel G, Falck JR, Shears SB, York JD, Mayr GW | 2009 Jan 16 | 18981179 |
| RHEA:10276 | 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8].[H+;H0:9]>>[*:1]-[O;H0;+0:2]-[P;H0;+0:4](=[*:3])(-[*:5])-[*:6].[*:8]-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. | Wang H, Falck JR, Hall TM, Shears SB | 2011 Nov 27 | 22119861 |
| Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. | Lin H, Fridy PC, Ribeiro AA, Choi JH, Barma DK, Vogel G, Falck JR, Shears SB, York JD, Mayr GW | 2009 Jan 16 | 18981179 |