EC number:2.7.4.29
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.4 Phosphotransferases with a phosphate group as acceptor |
| ID: | 2.7.4.29 |
|---|---|
| Description: | Kdo(2)-lipid A phosphotransferase. |
| Alternative Name: |
Lipid A undecaprenyl phosphotransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.4.29 |
| BRENDA Enzyme Link: | BRENDA 2.7.4.29 |
| KEGG Enzyme Link: | KEGG2.7.4.29 |
| BioCyc Enzyme Link: | BioCyc 2.7.4.29 |
| ExPASy Enzyme Link: | ExPASy2.7.4.29 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.4.29 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.4.29 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.4.29 |
| IntEnz Enzyme Link: | IntEnz 2.7.4.29 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.4.29 |
| RHEA:45468 | alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate = (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides. | Herrera CM, Hankins JV, Trent MS | 2010 Jun | 20384697 |
| Periplasmic phosphorylation of lipid A is linked to the synthesis of undecaprenyl phosphate. | Touzé T, Tran AX, Hankins JV, Mengin-Lecreulx D, Trent MS | 2008 Jan | 18047581 |