Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.4 Phosphotransferases with a phosphate group as acceptor
ID:2.7.4.6
Description:Nucleoside-diphosphate kinase.
Alternative Name: Nucleoside diphosphokinase.
Nucleoside 5'-diphosphate phosphotransferase.
NDK.
Prosite: PDOC00409;
PDB:
PDBScop
1U8W 8030462; 8042841; 8030462; 8042841; 8030462; 8042841; 8030462; 8042841; 8030462; 8042841; 8030462; 8042841;
5UI4 8030070; 8042449; 8030070; 8042449; 8030070; 8042449; 8030070; 8042449; 8030070; 8042449; 8030070; 8042449;
1JXV 8030070; 8042449; 8030070; 8042449; 8030070; 8042449; 8030070; 8042449; 8030070; 8042449; 8030070; 8042449;
3L7U 8030070; 8042449; 8030070; 8042449; 8030070; 8042449;
2HVD 8030070; 8042449; 8030070; 8042449; 8030070; 8042449;
 » show all

Cath: 3.30.70.141; 3.40.50.300;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.4.6
BRENDA Enzyme Link: BRENDA 2.7.4.6
KEGG Enzyme Link: KEGG2.7.4.6
BioCyc Enzyme Link: BioCyc 2.7.4.6
ExPASy Enzyme Link: ExPASy2.7.4.6
EC2PDB Enzyme Link: EC2PDB 2.7.4.6
ExplorEnz Enzyme Link: ExplorEnz 2.7.4.6
PRIAM enzyme-specific profiles Link: PRIAM 2.7.4.6
IntEnz Enzyme Link: IntEnz 2.7.4.6
MEDLINE Enzyme Link: MEDLINE 2.7.4.6
MSA:

2.7.4.6;

Phylogenetic Tree:

2.7.4.6;

Uniprot:
M-CSA:
RHEA:18113 a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

RHEA:25098 ATP + UDP = ADP + UTP
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

RHEA:25237 ATP + CDP = ADP + CTP
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

RHEA:27674 ATP + dADP = ADP + dATP
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

RHEA:27678 ATP + dCDP = ADP + dCTP
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

RHEA:27682 ATP + dTDP = ADP + dTTP
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

RHEA:27686 ATP + GDP = ADP + GTP
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

RHEA:27690 ATP + dGDP = ADP + dGTP
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

RHEA:28582 ATP + dUDP = ADP + dUTP
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

RHEA:30347 ATP + IDP = ADP + ITP
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

RHEA:30939 ATP + dIDP = ADP + dITP
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

RHEA:44640 a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Metabolism of deoxyribonucleotides. 3. Purification and some properties of nucleoside diphosphokinase of calf thymus.Nakamura H, Sugino Y1966 Nov 105925862