EC number:2.7.4.7

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.4 Phosphotransferases with a phosphate group as acceptor
ID:2.7.4.7
Description:Phosphooxymethylpyrimidine kinase.
Alternative Name: Phosphomethylpyrimidine kinase.
Hydroxymethylpyrimidine phosphokinase.
Cath: 3.40.1190.20; 1.20.910.10; 3.40.225.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.4.7
BRENDA Enzyme Link: BRENDA 2.7.4.7
KEGG Enzyme Link: KEGG2.7.4.7
BioCyc Enzyme Link: BioCyc 2.7.4.7
ExPASy Enzyme Link: ExPASy2.7.4.7
EC2PDB Enzyme Link: EC2PDB 2.7.4.7
ExplorEnz Enzyme Link: ExplorEnz 2.7.4.7
PRIAM enzyme-specific profiles Link: PRIAM 2.7.4.7
IntEnz Enzyme Link: IntEnz 2.7.4.7
MEDLINE Enzyme Link: MEDLINE 2.7.4.7

EC number:2.7.4.7

MSA:

2.7.4.7;
Phylogenetic Tree:

2.7.4.7;
Uniprot:
M-CSA:
RHEA:19893 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Characterization of two kinases involved in thiamine pyrophosphate and pyridoxal phosphate biosynthesis in Bacillus subtilis: 4-amino-5-hydroxymethyl-2methylpyrimidine kinase and pyridoxal kinase.Park JH, Burns K, Kinsland C, Begley TP2004 Mar14973012
Cloning and characterization of the thiD/J gene of Escherichia coli encoding a thiamin-synthesizing bifunctional enzyme, hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase.Mizote T, Tsuda M, Smith DD, Nakayama H, Nakazawa T1999 Feb10075431