EC number:2.7.4.9

Enzyme

Download
EC Tree
     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.4 Phosphotransferases with a phosphate group as acceptor
ID:2.7.4.9
Description:dTMP kinase.
Alternative Name: TMPK.
Thymidylic acid kinase.
Thymidylate kinase.
Prosite: PDOC01034;
PDB:
PDBScop
3N2I 8058439; 8058440; 8058439; 8058440;
3LV8 8058439; 8058440;
2W0S 8058437; 8058438; 8058437; 8058438;
2V54 8058437; 8058438; 8058437; 8058438;
3HJN 8058435; 8058436; 8058435; 8058436;
 » show all
Cath: 3.30.160.60; 3.30.60.20; 3.40.50.300;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.4.9
BRENDA Enzyme Link: BRENDA 2.7.4.9
KEGG Enzyme Link: KEGG2.7.4.9
BioCyc Enzyme Link: BioCyc 2.7.4.9
ExPASy Enzyme Link: ExPASy2.7.4.9
EC2PDB Enzyme Link: EC2PDB 2.7.4.9
ExplorEnz Enzyme Link: ExplorEnz 2.7.4.9
PRIAM enzyme-specific profiles Link: PRIAM 2.7.4.9
IntEnz Enzyme Link: IntEnz 2.7.4.9
MEDLINE Enzyme Link: MEDLINE 2.7.4.9

EC number:2.7.4.9

MSA:

2.7.4.9;
Phylogenetic Tree:

2.7.4.9;
Uniprot:
M-CSA:
RHEA:13517 ATP + dTMP = ADP + dTDP
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Isolation and characterization of an Escherichia coli mutant deficient in dTMP kinase activity.Daws TD, Fuchs JA1984 Feb6319360
Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes.Munier-Lehmann H, Chaffotte A, Pochet S, Labesse G2001 Jun11369858