Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.6 Diphosphotransferases
ID:2.7.6.1
Description:Ribose-phosphate diphosphokinase.
Alternative Name: Ribose-phosphate pyrophosphokinase.
Phosphoribosyl pyrophosphate synthetase.
Phosphoribosyl diphosphate synthetase.
Prosite: PDOC00105;
PDB:
PDBScop
1IBS 8019871; 8019873; 8032251; 8032253; 8019871; 8019873; 8032251; 8032253;
1DKU 8019871; 8019873; 8032251; 8032253; 8019871; 8019873; 8032251; 8032253;
1DKR 8019871; 8019873; 8032251; 8032253; 8019871; 8019873; 8032251; 8032253;
4S2U
4M0P
 » show all

Cath: 3.40.50.20; 3.40.50.2020;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.6.1
BRENDA Enzyme Link: BRENDA 2.7.6.1
KEGG Enzyme Link: KEGG2.7.6.1
BioCyc Enzyme Link: BioCyc 2.7.6.1
ExPASy Enzyme Link: ExPASy2.7.6.1
EC2PDB Enzyme Link: EC2PDB 2.7.6.1
ExplorEnz Enzyme Link: ExplorEnz 2.7.6.1
PRIAM enzyme-specific profiles Link: PRIAM 2.7.6.1
IntEnz Enzyme Link: IntEnz 2.7.6.1
MEDLINE Enzyme Link: MEDLINE 2.7.6.1
MSA:

2.7.6.1;

Phylogenetic Tree:

2.7.6.1;

Uniprot:
M-CSA:
RHEA:15609 ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](-[*:4])(=[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:7]-[O;H0;+0:8]-[P;H0;+0:3](-[*:4])(=[*:5])-[*:6].[*:1]-[OH;+0:2]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance.Hove-Jensen B, Andersen KR, Kilstrup M, Martinussen J, Switzer RL, Willemoës M2017 Mar28031352
Binding of divalent magnesium by Escherichia coli phosphoribosyl diphosphate synthetase.Willemoës M, Hove-Jensen B1997 Apr 229125530
PRS1 is a key member of the gene family encoding phosphoribosylpyrophosphate synthetase in Saccharomyces cerevisiae.Carter AT, Beiche F, Hove-Jensen B, Narbad A, Barker PJ, Schweizer LM, Schweizer M1997 Mar 269108276
Inactivation of Escherichia coli phosphoribosylpyrophosphate synthetase by the 2',3'-dialdehyde derivative of ATP. Identification of active site lysines.Hilden I, Hove-Jensen B, Harlow KW1995 Sep 17657655
Binding of the substrates and the allosteric inhibitor adenosine 5'-diphosphate to phosphoribosylpyrophosphate synthetase from Salmonella typhimurium.Gibson KJ, Schubert KR, Switzer RL1982 Mar 106277896
Regulation and mechanism of phosphoribosylpyrophosphate synthetase. 3. Kinetic studies of the reaction mechanism.Switzer RL1971 Apr 254324215
Regulation and mechanism of phosphoribosylpyrophosphate synthetase. I. Purification and properties of the enzyme from Salmonella typhimurium.Switzer RL1969 Jun 104306285
Wild-type phosphoribosylpyrophosphate synthase (PRS) from Mycobacterium tuberculosis: a bacterial class II PRS?Breda A, Martinelli LK, Bizarro CV, Rosado LA, Borges CB, Santos DS, Basso LA201222745722
Purification and properties of phosphoribosyl-diphosphate synthetase from Bacillus subtilis.Arnvig K, Hove-Jensen B, Switzer RL1990 Aug 282169413
Mycobacterium tuberculosis phosphoribosylpyrophosphate synthetase: biochemical features of a crucial enzyme for mycobacterial cell wall biosynthesis.Lucarelli AP, Buroni S, Pasca MR, Rizzi M, Cavagnino A, Valentini G, Riccardi G, Chiarelli LR2010 Nov 1521085589
Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase.Alderwick LJ, Lloyd GS, Lloyd AJ, Lovering AL, Eggeling L, Besra GS2011 Apr21045009
Novel class III phosphoribosyl diphosphate synthase: structure and properties of the tetrameric, phosphate-activated, non-allosterically inhibited enzyme from Methanocaldococcus jannaschii.Kadziola A, Jepsen CH, Johansson E, McGuire J, Larsen S, Hove-Jensen B2005 Dec 916288921
Catalytic residues Lys197 and Arg199 of Bacillus subtilis phosphoribosyl diphosphate synthase. Alanine-scanning mutagenesis of the flexible catalytic loop.Hove-Jensen B, Bentsen AK, Harlow KW2005 Jul16008562
Heterooligomeric phosphoribosyl diphosphate synthase of Saccharomyces cerevisiae: combinatorial expression of the five PRS genes in Escherichia coli.Hove-Jensen B2004 Sep 2415280369
Genetic analysis and enzyme activity suggest the existence of more than one minimal functional unit capable of synthesizing phosphoribosyl pyrophosphate in Saccharomyces cerevisiae.Hernando Y, Carter AT, Parr A, Hove-Jensen B, Schweizer M1999 Apr 3010212224