Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.6 Diphosphotransferases
ID:2.7.6.3
Description:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.
Alternative Name: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase.
7,8-dihydro-6-hydroxymethylpterin diphosphokinase.
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
6-hydroxymethyl-7,8-dihydropterin diphosphokinase.
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase.
Prosite: PDOC00631;
PDB:
PDBScop
5ETL 8032052; 8044430; 8032052; 8044430; 8032052; 8044430; 8032052; 8044430;
6AN6 8032052; 8044430; 8032052; 8044430;
4M5N 8032052; 8044430; 8032052; 8044430;
3HSD 8032052; 8044430; 8032052; 8044430;
1TMM 8032052; 8044430; 8032052; 8044430;
 » show all

Cath: 3.20.20.20; 3.30.1130.10; 3.30.1300.20; 3.30.70.560;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.6.3
BRENDA Enzyme Link: BRENDA 2.7.6.3
KEGG Enzyme Link: KEGG2.7.6.3
BioCyc Enzyme Link: BioCyc 2.7.6.3
ExPASy Enzyme Link: ExPASy2.7.6.3
EC2PDB Enzyme Link: EC2PDB 2.7.6.3
ExplorEnz Enzyme Link: ExplorEnz 2.7.6.3
PRIAM enzyme-specific profiles Link: PRIAM 2.7.6.3
IntEnz Enzyme Link: IntEnz 2.7.6.3
MEDLINE Enzyme Link: MEDLINE 2.7.6.3
MSA:

2.7.6.3;

Phylogenetic Tree:

2.7.6.3;

Uniprot:
M-CSA:
RHEA:11412 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](-[*:4])(=[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:7]-[O;H0;+0:8]-[P;H0;+0:3](-[*:4])(=[*:5])-[*:6].[*:1]-[OH;+0:2]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A bifunctional protein in the folate biosynthetic pathway of Streptococcus pneumoniae with dihydroneopterin aldolase and hydroxymethyldihydropterin pyrophosphokinase activities.Lopez P, Lacks SA1993 Apr8385663
The biosynthesis of folic acid. IX. Purification and properties of the enzymes required for the formation of dihydropteroic acid.Richey DP, Brown GM1969 Mar 254304228
DNA sequence of folate biosynthesis gene sulD, encoding hydroxymethyldihydropterin pyrophosphokinase in Streptococcus pneumoniae, and characterization of the enzyme.Lopez P, Greenberg B, Lacks SA1990 Sep2168367
Purification and partial characterization of 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase and 7,8-dihydropteroate synthase from Escherichia coli MC4100.Talarico TL, Dev IK, Dallas WS, Ferone R, Ray PH1991 Nov1657875
Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growth.Güldener U, Koehler GJ, Haussmann C, Bacher A, Kricke J, Becher D, Hegemann JH2004 Aug15169867